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UnknownResidual apoptotic activity of a tumorigenic p53 mutant improves cancer therapy responses
Not available
S-SCDT-EMBOJ-2019-102096 | biostudies-other
GenomicsChipSeq of conditional knock-in mouse carrying the R178E (EE) mutation in exon 5 of the endogenous mouse Trp53 gene locus.
The mouse R178E (EE) mutation of the Trp53 is a p53 mutant protein with native conformation that lacks the ability to form tetramers and thus constitutes a mutant form of p53 that lacks DNA binding cooperativity. Here we want to assess DNA binding ability of the EE mutant in MEFs under untreated con...
ORGANISM(S): Mus musculus 
2019-09-03 | E-MTAB-6793 | biostudies-arrayexpress
TranscriptomicsResidual tumor suppressor activities of tumorigenic p53 mutants enhance survival under chemotherapy
p53 mutations are believed to correlate with poor patient survival, as mutations abolish the transcriptional function of wild-type p53 in the DNA damage response and mutant p53 gain-of-function activities enhance drug resistance. Moreover, p53 also exhibits non-transcriptional apoptotic activity wit...
ORGANISM(S): Mus musculus 
2019-09-03 | E-MTAB-6774 | biostudies-arrayexpress
UnknownElliptic anisotropy measurement of the f<sub>0</sub>(980) hadron in proton-lead collisions and evidence for its quark-antiquark composition.
Not available
S-EPMC12391314 | biostudies-literature
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