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ProteomicsEnhanced antigen cross-presentation in human colorectal cancer-associated fibroblasts through upregulation of the lysosomal protease Cathepsin S
Cross-presentation of exogenous antigens in HLA-class I molecules by professional antigen presenting cells (APCs) is crucial for CD8+ T cell function. Recent murine studies show that several non-professional APCs, including cancer-associated fibroblasts (CAFs) also possess this capacity. It is curre...
ORGANISM(S): Homo sapiens (Human) 
2022-03-03 | PXD029507 | Pride
Tumor immunology Non-professional antigen presentation Parallel reaction monitoring Stromal immunobiology 
GenomicsHuman pancreatic ductal cells from non-T1D donors respond to T1D cytokines and function as non-professional antigen presenting cells
Human pancreatic ductal cells from non-T1D donors respond to T1D cytokines and function as non-professional antigen presenting cells
PRJNA1335105 | ENA
TranscriptomicsHuman pancreatic ductal cells from non-T1D donors respond to T1D cytokines and function as non-professional antigen presenting cells
Aims/Hypothesis: Type 1 diabetes (T1D) is an autoimmune disease marked by the destruction of beta cells in the pancreatic islets, with an incomplete picture of disease pathogenesis/progression and a lack of definitive cure. A recent finding linked pancreatic ductal cells of T1D donors with elevated ...
ORGANISM(S): Homo sapiens 
2025-09-30 | GSE309294 | GEO
TranscriptomicsGene expression analysis of molecules with known function in HLA class II antigen processing and presentation in hematopoietic and (cytokine pre-treated) non-hematopoietic cells.
Gene expression analysis of molecules with known function in HLA class II antigen processing and presentation. Various hematopoietic cell types and (cytokine pre-treated) non-hematopoietic cells that are targeted in Graft-versus-Leukemia reactivity and Graft-versus-Host Disease were collected. Expre...
ORGANISM(S): Homo sapiens 
2012-06-18 | E-GEOD-38798 | biostudies-arrayexpress
TranscriptomicsThe role of antigen presenting cells in the induction of HIV-1 latency in resting CD4+ T-cells
BACKGROUND: Combination antiretroviral therapy (cART) is able to control HIV-1 viral replication, however long-lived latent infection in resting memory CD4+ T-cells persist. The mechanisms for establishment and maintenance of latent infection in resting memory CD4+ T-cells remain unclear. Previously...
ORGANISM(S): Homo sapiens 
2015-12-23 | E-GEOD-70106 | biostudies-arrayexpress
ModelsWodarz2003 - Cytotoxic T lymphocyte cross-priming
This a model from the article: A dynamical perspective of CTL cross-priming and regulation: implications for cancer immunology. Wodarz D, Jansen VA. Immunol Lett 2003 May 1;86(3):213-27 12706524 , Abstract: ...
2024-09-02 | BIOMD0000000685 | BioModels
GenomicsLung tumor MHCII immunity depends on in situ antigen presentation by fibroblasts. [CAF]
Lung tumor MHCII immunity depends on in situ antigen presentation by fibroblasts. [CAF]
PRJNA691511 | ENA
GenomicsLung tumor MHCII immunity depends on in situ antigen presentation by fibroblasts. [CD4 T cells]
Lung tumor MHCII immunity depends on in situ antigen presentation by fibroblasts. [CD4 T cells]
PRJNA691510 | ENA
TranscriptomicsLung tumor MHCII immunity depends on in situ antigen presentation by fibroblasts. [CAF]
A key unknown of the functional space in tumor immunity is whether physiologically relevant cancer antigen presentation occurs solely in draining lymph nodes versus tumors. Professional antigen presenting cells, i.e. the dendritic cells, are scarce and immature within tumors, greatly outnumbered by ...
ORGANISM(S): Mus musculus 
2021-12-13 | GSE164653 | GEO
TranscriptomicsLung tumor MHCII immunity depends on in situ antigen presentation by fibroblasts. [CD4 T cells]
A key unknown of the functional space in tumor immunity is whether physiologically relevant cancer antigen presentation occurs solely in draining lymph nodes versus tumors. Professional antigen presenting cells, i.e. the dendritic cells, are scarce and immature within tumors, greatly outnumbered by ...
ORGANISM(S): Mus musculus 
2021-12-13 | GSE164659 | GEO
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