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MetabolomicsRibosomal mistranslation leads to silencing of the unfolded protein response and increased mitochondrial biogenesis

Translation fidelity is the limiting factor in the accuracy of gene expression. With an estimated frequency of 10-4, errors in mRNA decoding occur in a mostly stochastic manner. Little is known about the response of higher eukaryotes to chronic loss of ribosomal accuracy as per an increase in the...

2019-09-17 | MTBLS106 | MetaboLights
MetabolomicsSerum protein N-glycosylation changes in multiple myeloma

BACKGROUND: Multiple myeloma is characterized by clonal proliferation of malignant plasma cells in the bone marrow that produce monoclonal immunoglobulins. N-glycosylation changes of these monoclonal immunoglobulins have been reported in multiple myeloma, but previous studies on...

2022-04-27 | MTBLS676 | MetaboLights
MetabolomicsATAD3A has a scaffolding role regulating mitochondria inner membrane structure and protein assembly

The ATPase Family AAA Domain Containing 3A (ATAD3A), is a mitochondrial inner membrane protein conserved in metazoans. ATAD3A has been associated with several mitochondrial functions, including nucleoid organization, cholesterol metabolism, and mitochondrial translation. To address its primary ro...

2022-01-14 | MTBLS3786 | MetaboLights
MetabolomicsNew plasma preparation approach to enrich metabolome coverage in untargeted metabolomics: plasma protein bound hydrophobic metabolite release with proteinase K
Plasma untargeted metabolomics is a common method for evaluation of the mechanisms underlying human pathologies and identification of novel biomarkers. The plasma proteins provide the environment for transport of hydrophobic metabolites. The current sample preparation protocol relies on the immediat...
2022-03-18 | MTBLS670 | MetaboLights
GenomicsHuman endothelial cells stimulated with dengue virus non-structural protein 1
Human endothelial cells stimulated with dengue virus non-structural protein 1
PRJNA580464 | ENA
GenomicsA secreted viral non-structural protein determines intestinal norovirus pathogenesis and vaccination
Secreted non-structural protein 1 of norovirus counteracts IFN-l immunity and is a vaccine target.
PRJEB27021 | ENA
ProteomicsNetwork of interactions between ZIKA virus non-structural proteins and human host proteins
The Zika virus (ZIKV) is a mosquito-borne Flavivirus and can be transmitted through an infected mosquito bite or through human-to-human interaction by sexual activity, blood transfusion, breastfeeding or perinatal exposure. After the 2015-2016 outbreak in Brazil, a strong link between ZIKV infection...
ORGANISM(S): Homo sapiens (Human) 
2020-06-18 | PXD014961 | Pride
Zikv Non-structural viral proteins Network Protein-protein interaction 
TranscriptomicsRNA-Seq of SARS-CoV-2 Nucleocapsid protein expression in human embryonic kidney cell line HEK293
The RNA genome of the SARS-CoV-2 virus encodes for four structural proteins, 16 non-structural proteins and nine putative accessory factors. A high throughput analysis of interactions between human and SARS-CoV-2 proteins identified multiple interactions of the structural Nucleocapsid (N) protein wi...
ORGANISM(S): Homo sapiens 
2024-09-16 | E-MTAB-14342 | biostudies-arrayexpress
GenomicsThe Influenza non-structural protein 1 (NS1) operates targeted mechanisms to suppress immune gene expression.
The Influenza non-structural protein 1 (NS1) operates targeted mechanisms to suppress immune gene expression.
PRJNA656848 | ENA
GenomicsEffect of non-structural protein 1 (NS1) of H5N1 on CK2 expression, p53 signaling pathway and cell proliferation
Effect of non-structural protein 1 (NS1) of H5N1 on CK2 expression, p53 signaling pathway and cell proliferation
PRJNA1122121 | ENA
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