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MetabolomicsDT-109 ameliorates nonalcoholic steatohepatitis in nonhuman primates

Nonalcoholic steatohepatitis (NASH) prevalence is rising with no pharmacotherapy approved. A major hurdle in NASH drug development is the poor translatability of preclinical studies to safe/effective clinical outcomes, and recent failures highlight a need to identify new targetable pathways. Dysr...

2023-04-13 | MTBLS5005 | MetaboLights
MetabolomicsInvolvement of the Gut Microbes Romboutsia hominis and Akkermansia muciniphila in the Pathophysiology and Development of Nonalcoholic Steatohepatitis
Background Nonalcoholic steatohepatitis (NASH) represents a growing global health challenge due to its propensity to progress to irreversible hepatic disorders, including fibrosis, cirrhosis, and carcinoma. This study aimed to investigate the role of gut microbiota in the pathogenesis of NASH. We ha...
2025-06-23 | MTBLS12631 | MetaboLights
MetabolomicsNonalcoholic steatohepatitis (NASH) changes with S.Q. Leptin administrations
Not available
ORGANISM(S): Homo sapiens 
ST000677 | MetabolomicsWorkbench
MetabolomicsDistinct Human Hepatocyte Lipidomics Profiles for Nonalcoholic Steatohepatitis and In Vitro-Induced Steatosis
Not available
ORGANISM(S): Homo sapiens 
ST002057 | MetabolomicsWorkbench
TranscriptomicsExpression data from mouse liver treated with metformin
Optimal treatment for nonalcoholic steatohepatitis (NASH) has not yet been established, particularly for individuals without diabetes. We examined the effects of metformin, commonly used to treat patients with type 2 diabetes, on liver pathology in a non-diabetic NASH mouse model. Eight-week-old C57...
ORGANISM(S): Mus musculus 
2012-02-21 | E-GEOD-35961 | biostudies-arrayexpress
MetabolomicsIntestinal TM6SF2 Protects Against Metabolic Dysfunction-associated Steatohepatitis through the Gut-Liver Axis

Transmembrane-6 superfamily member 2 (TM6SF2) regulates hepatic fat metabolism and is closely associated with metabolic dysfunction-associated steatohepatitis (MASH). MASH involves genetic predisposition and gut microbiota alteration, yet the role of host-microbes interaction in disease developme...

2024-10-08 | MTBLS11004 | MetaboLights
ProteomicsAmelioration of nonalcoholic fatty liver disease by inhibiting the deubiquitylating enzyme RPN11
Nonalcoholic fatty liver disease (NAFLD) including its more severe manifestation, nonalcoholic steatohepatitis (NASH), is a global public health challenge. Here, we reveal a role for the deubiquitinating enzyme RPN11 in the development of NAFLD and NASH. Ablation of hepatic RPN11 markedly protected ...
ORGANISM(S): Homo Sapiens Mus Musculus 
2024-06-15 | PXD053163 |
MetabolomicsGut Microbiota Regulates Serum Metabolites in Mice with Nonalcoholic Fatty Liver Disease via Gut Metabolites: Mechanisms Involving Branched-Chain Amino Acids and Unsaturated Fatty Acids

In recent years, nonalcoholic fatty liver disease (NAFLD) has become the most common chronic liver disease globally. Studies indicate that the gut-liver axis plays an important role in the occurrence and development of this disease. Our previous studies showed that the gut microbiota and gut meta...

2025-07-02 | MTBLS12668 | MetaboLights
TranscriptomicsTranscription profiling of rat non-alcoholic Steatohepatitis following feeding of high polyunsaturated fat diets
Most commonly used models of non-alcoholic steatohepatitis (NASH) are diets based on specific gene knockouts or represent extreme manipulations of diet. We have examined the effects of modest increased caloric intake and high dietary unsaturated fat content on the development of NASH in male rats us...
ORGANISM(S): Rattus norvegicus 
2008-06-20 | E-GEOD-8253 | biostudies-arrayexpress
MetabolomicsStudy on the Hepatoprotection of Schisandra chinensis Caulis Ploysaccharides in nonalcoholic fatty liver disease in rats based on metabolomics

The aim of this study was to investigate the hepatoprotection of Schisandra chinensis Caulis polysaccharides (SCP) in the nonalcoholic fatty liver disease (NAFLD) induced by high-fat diet (HFD) in rats. A total of 30 Wistar rats were randomly divided into control group (CON), model group...

2021-08-24 | MTBLS3194 | MetaboLights
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