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We uncover a novel mechanism whereby developmental pathways are reactivated in adults to promote regeneration.
ORGANISM(S): Homo sapiens (Human) 
2019-05-23 | PXD013854 | Pride
Noncoding dsRNA induces retinoic acid synthesis to stimulate hair follicle regeneration via TLR3
This SuperSeries is composed of the SubSeries listed below. How developmental programs reactivate in regeneration is a fundamental question in biology. We addressed this question through the study of Wound Induced Hair follicle Neogenesis (WIHN), an adult organogenesis model where stem cells regener...
ORGANISM(S): Mus musculus Homo sapiens 
2019-05-22 | GSE128868 | GEO
Purpose: The purpose of this experiment is to expand the repertoire of C. elegans edited transcripts and identify the roles of ADR-1 as indirect regulator of editing and ADR-2 as the only active deaminase in vivo. Methods: Strand-specific RNA sequencing of wild-type and adr mutant worms, followed by...
ORGANISM(S): Caenorhabditis elegans 
Dicer is a central enzymatic player in RNA interference (RNAi) pathways that acts to regulate gene expression in nearly all eukaryotes. Although the cytoplasmic function of Dicer is well documented in mammals, there is little known about any possible nuclear function. Here we show that Dicer is pre...
ORGANISM(S): Homo sapiens 
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