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TranscriptomicsGene expression profile of patients with moderate and severe chronic spontaneous urticaria
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2017-04-19 | E-GEOD-72542 | biostudies-arrayexpress
TranscriptomicsGene expression profile of patients with moderate and severe chronic spontaneous urticaria [tissue]
Chronic spontaneous urticaria (CSU), also traditionally called Chronic Idiopathic Urticaria (CIU), is a common dermatosis. Its estimated point prevalence is 0.6 to 1%. CSU is defined by spontaneously occurring short-lived and itching wheal, angioedema or both. The current nomenclature of urticaria e...
ORGANISM(S): Homo sapiens 
2017-04-19 | E-GEOD-72540 | biostudies-arrayexpress
TranscriptomicsGene expression profile of patients with moderate and severe chronic spontaneous urticaria [blood]
Chronic spontaneous urticaria (CSU), also traditionally called Chronic Idiopathic Urticaria (CIU), is a common dermatosis. Its estimated point prevalence is 0.6 to 1%. CSU is defined by spontaneously occurring short-lived and itching wheal, angioedema or both. The current nomenclature of urticaria e...
ORGANISM(S): Homo sapiens 
2017-04-19 | E-GEOD-72541 | biostudies-arrayexpress
TranscriptomicsExpression data from MALD1 and MCL cases
Patients with conventional mantle cell lymphoma (MCL) show an aggressive clinical behavior. However, cases fulfilling the WHO criteria for MCL, but that remain asymptomatic without treatment, have been reported. In an attempt to understand this heterogeneity, we have compared 17 typical cases of MCL...
ORGANISM(S): Homo sapiens 
2013-12-23 | E-GEOD-45717 | biostudies-arrayexpress
TranscriptomicsLOXL2 dependent genes in RA induced mES differentiation
Our results indicate that oxidation of TAF10 by LOXL2 induces its release from its promoters, leading to a block in TFIID-dependent gene transcription. Since TFIID complex is crucial for the expression of Nanog, Klf4, Sox2 and Oct4 and for maintaining the pluripotent state of embryonic stem cells, T...
ORGANISM(S): Mus musculus 
2015-12-21 | E-GEOD-65675 | biostudies-arrayexpress
TranscriptomicsSearch for specific biomarkers of IFN-beta bioactivity in patients with MS
We aimed to identify specific biomarkers of IFN-beta bioactivity in order to compare their gene expression induction by type I IFNs with the MxA, and to investigate their potential role in MS pathogenesis. Gene expression microarrays were performed in PBMC from MS patients who developed neutralizing...
ORGANISM(S): Homo sapiens 
2010-12-18 | E-GEOD-26104 | biostudies-arrayexpress
TranscriptomicsThe PRC1 protein RING1B contributes to Ewing sarcoma tumorigenesis by repressing the NaV1.6 sodium channel and modulating the NF-kB pathway, independently of the fusion oncoprotein.
Ewing sarcoma (ES) is an aggressive tumor molecularly defined by reciprocal translocations of EWSR1 to an ETS transcription factor. The functions of EZH2 and BMI1, two proteins of the Polycomb group (PcG) of epigenetic repressors, have been previously shown to mediate specific features in EWSR1/ETS-...
ORGANISM(S): Homo sapiens 
2016-06-30 | E-GEOD-71007 | biostudies-arrayexpress
TranscriptomicsBRAF-induced tumorigenesis is IKKalpha dependent but NF?B independent
Tumor cells carrying KRAS mutations activate the NF-?B pathway by different mechanisms, which contribute to the acquisition of essential cancer properties. The BRAF kinase, a downstream mediator of KRAS, is also mutated in a subset of colorectal cancers (CRC), which predicts bad prognosis and therap...
ORGANISM(S): Homo sapiens 
2015-05-08 | E-GEOD-57979 | biostudies-arrayexpress
TranscriptomicsGene expression from human fibroblasts
Since the initial discovery that OCT4, SOX2, KLF4 and c-MYC overexpression sufficed for the induction of pluripotency in somatic cells, methodologies replacing the original factors have enhanced our understanding of the reprogramming process. However, unlike in mouse, OCT4 has not been replaced succ...
ORGANISM(S): Homo sapiens 
2013-12-31 | E-GEOD-48275 | biostudies-arrayexpress
TranscriptomicsDifferential gene expression profiles between Parp-2-/- and wild-type hematopoietic stem/progenitors cell at basal and in response to 5 Gy gamma Irradiation (2.5 hours post-irradiation)
Gene expression profile between Parp-2-/- and wild-type hematopoietic stem/progenitor cells at basal and to the early response (2.5 hours) to 5 Gy total body irradiation We analyzed 2 arrays from each condition. Each samples represent a pool of at least 3 mice
ORGANISM(S): Mus musculus 
2013-08-06 | E-GEOD-42022 | biostudies-arrayexpress
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