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MetabolomicsSerum organic acid metabolites can be used as potential biomarkers to identify prostatitis, benign prostatic hyperplasia, and prostate cancer (Untargeted assay)

BACKGROUND: Noninvasive methods for the early identify diagnosis of prostatitis, benign prostatic hyperplasia (BPH), and prostate cancer (PCa) are current clinical challenges.

METHODS: The serum metabolites of 20 healthy individuals and patients with prosta...

2023-04-17 | MTBLS6039 | MetaboLights
MetabolomicsSerum organic acid metabolites can be used as potential biomarkers to identify prostatitis, benign prostatic hyperplasia, and prostate cancer (Targeted organic acid assay)

BACKGROUND: Noninvasive methods for the early identify diagnosis of prostatitis, benign prostatic hyperplasia (BPH) and prostate cancer (PCa) are current clinical challenges.

METHODS: The serum metabolites of 20 healthy individuals and patients with prostat...

2023-04-17 | MTBLS6038 | MetaboLights
TranscriptomicsTranscription profiling of normal, tumor and pure stromal tissue samples from patients with prostate adenocarcinoma, together with 4 cell lines
We have used normal, tumoral and pure stromal whole tissue samples, and cells lines in order to identify new markers of prostate cancer.
The normal, tumoral and stromal tissue were obtained from patients diagnosed with prostate adenocarcinoma.
ORGANISM(S): Homo sapiens 
2008-11-12 | E-MEXP-1331 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human prostate samples from normal donors and prostate cancer patients
This SuperSeries is composed of the following subset Series:; GSE6604: Expression data from Normal Prostate Tissue free of any pathological alteration; GSE6605: Expression data from Metastatic Prostate Tumor; GSE6606: Expression data from Primary Prostate Tumor; GSE6608: Expression data from Normal ...
ORGANISM(S): Homo sapiens 
2008-04-06 | E-GEOD-6919 | biostudies-arrayexpress
TranscriptomicsGene expression programs of histologically distinct stages of prostate carcinogenesis in Nkx3.1; Pten mutant mice
Key histological and growth progression characteristics of human prostate cancer are phenocopied in mouse models that have been subjected to androgen level depletion and engineered for hemizygosity of candidate prostate cancer tumor suppressor genes Nkx3.1 and Pten. To characterize their relative tr...
ORGANISM(S): Mus musculus 
2009-10-31 | E-GEOD-15943 | biostudies-arrayexpress
TranscriptomicsNormal vs. Tumor Prostate miRNA
Comparison of miRNA expression profiles in a small set of prostate needle core biopsies or fine needle aspirates. Keywords: Expression profiling of prostate needle core biopsies MicroRNA expression was compared between a pooled normal sample consisting of 10 separate normal adjacent to tumor prost...
ORGANISM(S): Homo sapiens 
2010-06-11 | E-GEOD-4574 | biostudies-arrayexpress
TranscriptomicsProstate CancerM-bM-^@M-^SAssociated Gene Expression Alterations Determined from Needle Biopsies
To accurately identify gene expression alterations that differentiate neoplastic from normal prostate epithelium using an approach that avoids contamination by unwanted cellular components and is not compromised by acute gene expression changes associated with tumor devascularization and resulting i...
ORGANISM(S): Homo sapiens 
2012-08-24 | E-GEOD-40373 | biostudies-arrayexpress
TranscriptomicsCells Comprising the Prostate Cancer Microenvironment Lack Recurrent Clonal Somatic Genomic Aberrations
Prostate cancer-associated stroma (CAS) plays an active role in malignant transformation, tumor progression, and metastasis. Molecular analyses of CAS have demonstrated significant changes in gene expression; however, conflicting evidence exists on whether genomic alterations in benign cells compris...
ORGANISM(S): Homo sapiens 
2016-02-12 | E-GEOD-76456 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of normal prostates and prostate cancer metastases
Gene expression profiling of normal prostates from organ donors and prostate cancer metastases from a rapid autopsy cohort of lethal metastatic prostate cancer Multiple anatomically distinct metastases (18) from each of five patients. 21 normal prostate samples from organ donors
ORGANISM(S): Homo sapiens 
2013-02-04 | E-GEOD-38241 | biostudies-arrayexpress
TranscriptomicsDNA methylation profiling of normal prostates and prostate cancer metastases [Illumina]
DNA methylation profiling of normal prostates from organ donors and prostate cancer metastases from a rapid autopsy cohort of lethal metastatic prostate cancer Metastases from prostate cancer patients. Normal prostate samples from organ donors
ORGANISM(S): Homo sapiens 
2013-02-04 | E-GEOD-38240 | biostudies-arrayexpress
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