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ProteomicsProteomics, post-translational modifications, and integrative analyses reveal heterogeneity of molecular mechanisms within medulloblastoma subgroups
Archer TC, Ehrenberger T, Mundt F, Gold MP, Krug K, Mah CK, Mahoney EL, Daniel CJ, LeNail A, Ramamoorthy D, Mertins P, Mani DR, Zhang H, Gillette MA, Clauser K, Noble M, Tang LC, Francois JP, Silterra J, Jensen J, Tamayo P, Korshunov A, Pfister SM, Kool M, Northcott PA, Sears RC, Lipton JO, Carr SA,...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2018-07-20 | MSV000082644 | MassIVE
TranscriptomicsGenomics of medulloblastoma identifies four distinct molecular variants
Recent genomic approaches have suggested the existence of multiple distinct subtypes of medulloblastoma. We studied a large cohort of medulloblastomas to determine how many subgroups of the disease exist, how they differ, and the extent of overlap between subgroups. We determined gene expression p...
ORGANISM(S): Homo sapiens 
2010-09-13 | E-GEOD-21140 | biostudies-arrayexpress
TranscriptomicsThe miR-17/92 Polycistron Is Up-regulated in Sonic Hedgehog-Driven Medulloblastomas and Induced by N-myc in Sonic Hedgehogâ??Treated Cerebellar Neural Precursors
Medulloblastoma is the most common malignant pediatric brain tumor, and mechanisms underlying its development are poorly understood. We identified recurrent amplification of the miR-17/92 polycistron proto-oncogene in 6% of pediatric medulloblastomas by high-resolution single-nucleotide polymorphism...
ORGANISM(S): Homo sapiens 
2010-04-14 | E-GEOD-21166 | biostudies-arrayexpress
UnknownRevised clinical and molecular risk strata define the incidence and pattern of failure in medulloblastoma following risk-adapted radiotherapy and dose-intensive chemotherapy: results from a phase III multi-institutional study.
Not available
S-EPMC9248404 | biostudies-literature
UnknownTargeting the enhancer of zeste homologue 2 in medulloblastoma.
Not available
S-EPMC3375399 | biostudies-literature
GenomicsHypermutation of the inactive X chromosome is a frequent event in cancer
Mutation is a fundamental process in tumorigenesis. However the degree to which the rate of somatic mutation varies across the human genome and the mechanistic basis underlying this variation remain to be fully elucidated. As part of the ICGC PedBrain and Malignant Lymphoma (MMML-Seq) consortium we ...
EGAS00001000565 | EGA
TranscriptomicsSubgroup specific somatic copy number aberrations in the medulloblastoma genome [gDNA]
Affymetrix SNP6 profiling of 1087 medulloblastoma samples and 10 medulloblastoma cell lines. Genomic DNA was extracted from primary medulloblastoma samples and medulloblastoma cell lines and hybridized to Affymetrix SNP6 arrays according to the manufacturer's instructions.
ORGANISM(S): Homo sapiens 
2012-07-26 | E-GEOD-37384 | biostudies-arrayexpress
UnknownWNT-activated embryonal tumors of the pineal region: ectopic medulloblastomas or a novel pineoblastoma subgroup?
Not available
S-EPMC7501206 | biostudies-literature
UnknownEfficacy of Carboplatin and Isotretinoin in Children With High-risk Medulloblastoma: A Randomized Clinical Trial From the Children's Oncology Group.
Not available
S-EPMC8299367 | biostudies-literature
TranscriptomicsSubgroup specific somatic copy number aberrations in the medulloblastoma genome [mRNA]
Affymetrix Human Gene 1.1 ST Array profiling of 285 primary medulloblastoma samples. Total RNA was extracted from primary medulloblastoma samples and hybridized to Affymetrix Human Gene 1.1 ST Arrays (24-Array Plates) according to the manufacturer's instructions.
ORGANISM(S): Homo sapiens 
2012-07-26 | E-GEOD-37382 | biostudies-arrayexpress
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