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GenomicsH2A.Z Facilitates Access of Active and Repressive Complexes to Chromatin in Embryonic Stem Cell Self-renewal and Differentiation
Chromatin modifications have been implicated in the self-renewal and differentiation of embryonic stem cells (ESCs). However, the function of histone variant H2A.Z in ESCs remains unclear. We show that H2A.Z is highly enriched at promoters and enhancers and is required for both efficient self-renewa...
ORGANISM(S): Mus musculus 
2012-12-20 | E-GEOD-34483 | biostudies-arrayexpress
TranscriptomicsRegulation of nucleosome landscape and transcription factor binding at enhancers by BRG1
Enhancers of transcription activate transcription via binding of sequence-specific transcription factors to their target sites in chromatin. In this report, we identify GATA1-bound enhancers genome-wide and find a global reorganization of the nucleosomes at these enhancers during differentiation of ...
ORGANISM(S): Homo sapiens 
2011-07-01 | E-GEOD-26501 | biostudies-arrayexpress
GenomicsGenome-wide Analyses of Transcription Factor GATA3-Mediated Gene Regulation in Distinct T Cell Types
We report genome-wide characterization of GATA3 binding sites in eleven well-defined developmental and effector cell types of the T lymphocyte lineage. By utilizing a conditional allele of GATA3, we investigated the impact of GATA3 expression on the mRNA expression patterns in several of these cell...
ORGANISM(S): Mus musculus 
2011-08-26 | E-GEOD-20898 | biostudies-arrayexpress
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