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ProteomicsThe non-canonical poly(A) polymerase FAM46C acts as an onco-suppressor in multiple myeloma
FAM46C is one of the most frequently mutated genes in multiple myeloma (MM). Here, using a combination of in vitro and in vivo approaches, we demonstrate that FAM46C encodes an active non-canonical poly(A) polymerase which enhances mRNA stability and gene expression. Reintroduction of active FAM46C i...
ORGANISM(S): Homo sapiens (Human) 
2018-03-09 | PXD006790 | Pride
Lc-msms Fam46c Anemia Mouse B lymphocytes Polyadenylation Multiple myeloma 
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ProteomicsTrinucleotide cap analogs with N6-adenosine modifications: interaction partners in HEK293F cell line
A series of trinucleotide cap analogs functionalized with an amine-terminated linker at the guanosine ribose and immobilized on BrCN-activated Sepharose was prepared. These affinity resins AR-1 (Am), AR-2 (m6Am), and AR-3 (Bn6Am) were incubated with HEK293F cell extract in the presence of GTP to limi...
ORGANISM(S): Homo sapiens (Human) 
2024-03-08 | PXD046838 | Pride
5′ cap N6-benzyladenosine Mrna Hek293 N6-methyladenosine 
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UnknownThe potential of PARP inhibitors in targeted cancer therapy and immunotherapy.
Not available
S-EPMC9751342 | biostudies-literature
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UnknownThe identity and methylation status of the first transcribed nucleotide in eukaryotic mRNA 5' cap modulates protein expression in living cells.
Not available
S-EPMC7038993 | biostudies-literature
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Unknownp66Shc Protein-Oxidative Stress Sensor or Redox Enzyme: Its Potential Role in Mitochondrial Metabolism of Human Breast Cancer.
Not available
S-EPMC11476363 | biostudies-literature
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UnknownBone marrow is the preferred site of memory CD4+ T cell proliferation during recovery from sepsis.
Not available
S-EPMC7259529 | biostudies-literature
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UnknownValosin-containing protein (p97) is a regulator of endoplasmic reticulum stress and of the degradation of N-end rule and ubiquitin-fusion degradation pathway substrates in mammalian cells.
Not available
S-EPMC1635394 | biostudies-literature
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UnknownMyeloid Cell-Derived Arginase in Cancer Immune Response.
Not available
S-EPMC7242730 | biostudies-literature
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UnknownA novel function of VCP (valosin-containing protein; p97) in the control of N-glycosylation of proteins in the endoplasmic reticulum.
Not available
S-EPMC2040342 | biostudies-literature
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UnknownNon-Hematologic Toxicity of Bortezomib in Multiple Myeloma: The Neuromuscular and Cardiovascular Adverse Effects.
Not available
S-EPMC7563977 | biostudies-literature
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