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UnknownCrossregulation and functional redundancy between the splicing regulator PTB and its paralogs nPTB and ROD1.
Not available
S-EPMC1940037 | biostudies-literature
UnknownSolution and crystal structures of a C-terminal fragment of the neuronal isoform of the polypyrimidine tract binding protein (nPTB).
Not available
S-EPMC3961105 | biostudies-literature
GenomicsSequential regulatory loops as key gatekeepers for neuronal reprogramming in human cells [ChIP-seq]
Direct conversion of somatic cells into neurons holds great promise for regenerative medicine. However, neuronal conversion is relatively inefficient in human cells compared to mouse cells. It has been unclear what might be the key barriers to reprogramming in human cells. We recently elucidated an ...
ORGANISM(S): Homo sapiens 
2016-04-25 | GSE74814 | GEO
TranscriptomicsSequential regulatory loops as key gatekeepers for neuronal reprogramming in human cells [RNA-seq]
Direct conversion of somatic cells into neurons holds great promise for regenerative medicine. However, neuronal conversion is relatively inefficient in human cells compared to mouse cells. It has been unclear what might be the key barriers to reprogramming in human cells. We recently elucidated an ...
ORGANISM(S): Homo sapiens 
2016-04-25 | GSE77523 | GEO
UnknownCell-specific proteins regulate viral RNA translation and virus-induced disease.
Not available
S-EPMC125770 | biostudies-literature
TranscriptomicsPosition-dependent alternative splicing activity revealed by global profiling of alternative splicing events regulated by PTB (HJAY)
To gain global insights into the role of the well-known repressive splicing regulator PTB we analyzed the consequences of PTB knockdown in HeLa cells using high-density oliogonucleotide splice-sensitive microarrays. The major class of identified PTB-regulated splicing event was PTB-repressed cassett...
ORGANISM(S): Homo sapiens 
2010-09-01 | E-GEOD-23513 | biostudies-arrayexpress
TranscriptomicsPosition-dependent alternative splicing activity revealed by global profiling of alternative splicing events regulated by PTB (Exon array)
To gain global insights into the role of the well-known repressive splicing regulator PTB we analyzed the consequences of PTB knockdown in HeLa cells using high-density oliogonucleotide splice-sensitive microarrays. The major class of identified PTB-regulated splicing event was PTB-repressed cassett...
ORGANISM(S): Homo sapiens 
2010-09-01 | E-GEOD-23514 | biostudies-arrayexpress
UnknownCooperative assembly of an hnRNP complex induced by a tissue-specific homolog of polypyrimidine tract binding protein.
Not available
S-EPMC86300 | biostudies-literature
TranscriptomicsPTB CLIP-seq
Recent transcriptome analysis indicates that >90% of human genes undergoes alternative splicing, underscoring the contribution of differential RNA processing to diverse proteomes in higher eukaryotic cells. The polypyrimidine tract binding protein PTB is a well-characterized splicing repressor, but ...
ORGANISM(S): Homo sapiens 
2009-12-24 | E-GEOD-19323 | biostudies-arrayexpress
UnknownSequential regulatory loops as key gatekeepers for neuronal reprogramming in human cells.
Not available
S-EPMC4882254 | biostudies-literature
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