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TranscriptomicsGene Expression of Kidney from FHH and Nr4a1 Deficient Rats
Nr4a1 deficient rats (Nr4a1-/-) were developed using the fawn hooded hypertensive rat (FHH), which provided a genetic background susceptible to kidney injury. Both groups of animals were evaluated for blood pressure, proteinuria, renal function, and whole transcriptome gene pathway changes. Gene exp...
ORGANISM(S): Rattus norvegicus 
2014-02-06 | E-GEOD-54714 | biostudies-arrayexpress
TranscriptomicsNr4a1 and Nr4a3 upregulate cell cycle genes upregulated in the Nkx6.1 beta-cell proliferation pathway
Loss of functional beta-cell mass is a hallmark of Type 1 and Type 2 diabetes, and methods for restoring these cells are needed. Nkx6.1 induces beta-cell proliferation, but the pathway by which Nkx6.1 activates beta-cell expansion has not been defined. Here we demonstrate that Nkx6.1 induces express...
ORGANISM(S): Rattus norvegicus 
2014-02-18 | E-GEOD-55078 | biostudies-arrayexpress
TranscriptomicsNkx6.1 regulates islet beta-cell proliferation via Nr4a1 and Nr4a3 nuclear receptors
Loss of functional beta-cell mass is a hallmark of Type 1 and Type 2 diabetes, and methods for restoring these cells are needed. We have previously reported that overexpression of the homeodomain transcription factor Nkx6.1 in rat pancreatic islets induces beta-cell proliferation and enhances glucos...
ORGANISM(S): Rattus norvegicus 
2014-02-18 | E-GEOD-55077 | biostudies-arrayexpress
GenomicsGenome-wide ChIP-seq analysis of Nr4a1 binding sites in regulatory T (Treg) cells
We have revealed that Nr4a family nuclear orphan receptors broadly regulate a transcriptional program in Treg cells. In this study, to give an insight into Nr4a-mediated regulation of the transcriptional program in Treg cells, we performed ChIP-seq experiment using anti-Nr4a1 antibodies and a chroma...
ORGANISM(S): Mus musculus 
2015-06-30 | E-GEOD-70417 | biostudies-arrayexpress
TranscriptomicsActivity-induced Nr4a1 regulates spine density and distribution pattern of excitatory synapses in pyramidal neurons
Excitatory synapses occur mainly on dendritic spines, and spine density is usually correlated with the strength of excitatory synaptic transmission. We report that Nr4a1, an activity-inducible gene encoding a nuclear receptor, regulates the density and distribution of dendritic spines in CA1 pyramid...
ORGANISM(S): Mus musculus 
2016-01-13 | E-GEOD-76805 | biostudies-arrayexpress
TranscriptomicsExpression data of mouse hematopoietic cells, Nr4a1/3 wild type and double mutant
We investigate the cellular and molecular mechanisms of tumor suppression by NR4A1 and NR4A3, and show a cell intrinsic essential function in maintenance of hematopoietic stem cell (HSC) homeostasis. In the absence of Nr4a1/3, HSC lost quiescence, became highly proliferative leukemia-stem cell (LSC)...
ORGANISM(S): Mus musculus 
2013-12-30 | E-GEOD-31042 | biostudies-arrayexpress
GenomicsAnalysis of differentially expressed genes between circZbtb20+/+ and circZbtb20-/- ILC3s or between Nr4a1+/+ and Nr4a1-/- ILC3s
Analysis of differentially expressed genes between circZbtb20+/+ and circZbtb20-/- ILC3s or between Nr4a1+/+ and Nr4a1-/- ILC3s
PRJNA624309 | ENA
GenomicsRNA analysis of Nr4a1 and Nr4a1-knockout mammary tumor cells from MMTV-PyVT transgenic mice
RNA analysis of Nr4a1 and Nr4a1-knockout mammary tumor cells from MMTV-PyVT transgenic mice
PRJNA545286 | ENA
GenomicsOrphan nuclear receptor NR4A1 regulates both osteoblastogenesis and adipogenesis in human mesenchymal stem cells
The effect of NR4A1 in hMSCs
PRJEB60490 | ENA
GenomicsOrphan nuclear receptor NR4A1 regulates both osteoblastogenesis and adipogenesis in human mesenchymal stem cells
The effect of NR4A1 in hMSCs
PRJEB60491 | ENA
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