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GenomicsGenome-wide mapping of Nr5a2 in mouse embryonic stem cells
Nr5a2 (also known as liver receptor homolog-1, Lrh-1) has been shown to bind both the proximal enhancer and proximal promoter regions of Pou5f1 and regulate Pou5f1 in the epiblast stage of mouse embryonic development (Gu et al., 2005). Nr5a2-null embryos display a loss of Oct4 expression in the epib...
ORGANISM(S): Mus musculus 
2010-01-22 | E-GEOD-19019 | biostudies-arrayexpress
TranscriptomicsATACseq of TNG-A derived mESCs comparing WT to Dax1, Nr5a2 and Dax1/Nr5a2 knock-out clones
ATACseq in WT, Dax1, Nr5a2 and Dax1/Nr5a2 knock-out clones of mESCs in order to determine the role of the Dax1/Nr5a2 complex on chromatin accessibility and the activity of cis-regulatory elements during differentiation.
This experiment is part of the study: "Mechanistic framework of lineage rest...
ORGANISM(S): Mus musculus 
2021-03-15 | E-MTAB-9453 | biostudies-arrayexpress
TranscriptomicsZHBTc4 ES cells stably expressing EGFP vs Nr5a2-EGFP or Oct4-EGFP vs Nr5a2-EGFP
Gene expression profiles of ZHBTc4 ES cells expressing EGFP, Oct4-EGFP, Nr5a2-EGFP under CAG promoter. Monoclonal cell lines selected by Puromycin were used for analysis. Each of the cell lines was cultured in doxycycline containing media for endogenous Oct4 knock-down. Pupose of this experiment is...
ORGANISM(S): Mus musculus 
2013-11-05 | E-GEOD-52034 | biostudies-arrayexpress
GenomicsATACseq of TNG-A derived mESCs comparing WT to Dax1, Nr5a2 and Dax1/Nr5a2 knock-out clones
ATACseq of TNG-A derived mESCs comparing WT to Dax1, Nr5a2 and Dax1/Nr5a2 knock-out clones
PRJEB39929 | ENA
TranscriptomicsRNA-seq comparing WT to Dax1, Nr5a2 and Dax1/Nr5a2 knock-out clones in 2iLIF and SL differentiation conditions
Determine the transcriptomic effects that are associated with the knock-out of the inhibitor of PrE trans-differentiation Dax1 and the associated nuclear receptor Nr5a2.
This experiment is part of the study: "Mechanistic framework of lineage restriction in embryonic stem cells" by Olivieri et al.
ORGANISM(S): Mus musculus 
2021-03-15 | E-MTAB-9447 | biostudies-arrayexpress
GenomicsZygotic genome activation by the totipotency pioneer factor Nr5a2
Zygotic genome activation by the totipotency pioneer factor Nr5a2
PRJNA737805 | ENA
GenomicsZygotic genome activation by the totipotency pioneer factor Nr5a2
Zygotic genome activation by the totipotency pioneer factor Nr5a2
PRJNA739972 | ENA
GenomicsZygotic genome activation by the totipotency pioneer factor Nr5a2 II
Zygotic genome activation by the totipotency pioneer factor Nr5a2 II
PRJNA739907 | ENA
GenomicsZygotic genome activation by the totipotency pioneer factor Nr5a2 IV
Zygotic genome activation by the totipotency pioneer factor Nr5a2 IV
PRJNA882060 | ENA
GenomicsZygotic genome activation by the totipotency pioneer factor Nr5a2 III
Zygotic genome activation by the totipotency pioneer factor Nr5a2 III
PRJNA739975 | ENA
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