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ProteomicsNucleus-Translocated GCLM Promotes Chemoresistance in Colorectal Cancer through a Moonlighting Function
Emerging evidence indicates that metabolic enzymes perform moonlighting functions during tumor progression, including the modulation of chemoresistance. However, the underlying mechanisms of these functions remain elusive. In this study, utilizing a metabolic CRISPR-Cas9 knockout library screen, we ...
ORGANISM(S): Homo sapiens (Human) 
2024-11-15 | PXD055376 | Pride
Nuclear gclm  moonlighting function  nkrf  phosphorylation  chemoresistance lc-ms/ms 
GenomicsSTAT1-GCLM axis promotes B-cell expansion in adenoid hypertrophy
STAT1-GCLM axis promotes B-cell expansion in adenoid hypertrophy
PRJNA1458585 | ENA
OtherNucleus-Translocated GCLM Promotes Chemoresistance in Colorectal Cancer through a Moonlighting Function
Emerging evidence indicates that metabolic enzymes perform moonlighting functions during tumor progression, including the modulation of chemoresistance. However, the underlying mechanisms of these functions remain elusive. In this study, utilizing a genome-scale metabolic CRISPR-Cas9 knockout librar...
ORGANISM(S): Homo sapiens 
2024-01-28 | GSE254136 | GEO
GenomicsNucleus-Translocated GCLM Promotes Chemoresistance in Colorectal Cancer through a Moonlighting Function
Nucleus-Translocated GCLM Promotes Chemoresistance in Colorectal Cancer through a Moonlighting Function
PRJNA1068616 | ENA
TranscriptomicsSTAT1-GCLM axis promotes B-cell expansion in adenoid hypertrophy
Adenoid hypertrophy (AH) is a chronic inflammatory disorder characterized by pathological enlargement of nasopharyngeal lymphoid tissue, yet the mechanisms driving its progression remain unclear. Here, an LPS-induced inflammatory model was established in human immortalized B lymphoblastoid cells (B-...
ORGANISM(S): Mus musculus 
2026-06-30 | GSE329298 | GEO
UnknownNucleus-translocated GCLM promotes chemoresistance in colorectal cancer through a moonlighting function.
Not available
S-EPMC11696352 | biostudies-literature
UnknownNAA20-mediated ACF1 lactylation drives neuroblastoma progression through enhancing GCLM-dependent glutathione synthesis.
Not available
S-EPMC12906602 | biostudies-literature
GenomicsGenome-wide mapping of Nuclear Factor I binding sites using ChIP-Seq in WT and NFI-C knock-out MEFs
The Nuclear Factor I (NFI) family of DNA binding proteins (also called CAAT box transcription factors or CTF) is involved both in replication of adenoviral DNA and in regulation of gene expression. Using chromatin immuno-precipitation and high throughput sequencing (method termed ChIP-Seq) we perfor...
ORGANISM(S): Mus musculus 
2010-04-24 | E-GEOD-15844 | biostudies-arrayexpress
UnknownNuclear localization of glutamate-cysteine ligase is associated with proliferation in head and neck squamous cell carcinoma.
Not available
S-EPMC4887909 | biostudies-literature
UnknownTumour necrosis factor alpha induces co-ordinated activation of rat GSH synthetic enzymes via nuclear factor kappaB and activator protein-1.
Not available
S-EPMC1276939 | biostudies-literature
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