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MetabolomicsMetabolomic profiling of cerebrospinal fluid from dogs with meningoencephalitis of unknown origin by nuclear magnetic resonance

Introduction: Meningoencephalitis of unknown origin (MUO) in dogs is a very debilitating and potentially fatal disease that is a potential model for multiple sclerosis in humans. The metabolomic profile of MUO has not been previously reported.

Objectives: To describe the metabolomic profile...

2026-03-05 | MTBLS6053 | MetaboLights
TranscriptomicsKnock-out of the nuclear localization in pp65 protein of Cytomegalovirus: biologic and immunologic effects
The CMVpp65 protein contains 2 bipartite nuclear localization signals (NLS) at 415-438aa and 537-561aa near the carboxy terminus of CMVpp65 and a phosphate binding site related to kinase activity at lysine-436. A mutation of pp65 having K436N (CMVpp65mII) and further deletion of aa537-561 resulted ...
ORGANISM(S): Homo sapiens 
2009-01-30 | E-GEOD-14347 | biostudies-arrayexpress
GenomicsHNRNPU regulates lncRNAs nuclear localization
HNRNPU regulates lncRNAs nuclear localization
PRJNA694053 | ENA
GenomicsAltered Subcellular Localization of Transcription Factor TEAD4 Regulates First Mammalian Cell Lineage Commitment
In the preimplantation mouse embryo TEAD4 is critical to establishing the trophectoderm (TE)-specific transcriptional program and segregating TE from the inner cell mass (ICM). However, TEAD4 is expressed both in the TE and the ICM. Thus, differential function of TEAD4 rather than expression itself ...
ORGANISM(S): Mus musculus 
2012-04-18 | E-GEOD-37350 | biostudies-arrayexpress
TranscriptomicsCytoplasmic Assembly and Selective Nuclear Import of Arabidopsis ARGONAUTE4/siRNA Complexes
Here we profiled small RNAs from whole cell, cytoplasmic and nuclear extracts from three-week-old Arabidopsis seedlings. We unexpectedly found that nuclear functional hc-siRNAs are predominantly present in the cytoplasm. Samples from Arabidopsis thaliana whole cell, cytoplasmic and nuclear extract...
ORGANISM(S): Arabidopsis thaliana 
2012-07-12 | E-GEOD-36500 | biostudies-arrayexpress
ProteomicsNEAT1 Regulates BMSCs Aging Through Disruption of FGF2 Nuclear Transport
Background: The aging of bone marrow mesenchymal stem cells (BMSCs) impairs bone tissue regeneration, contributing to skeletal disorders. LncRNA NEAT1 is considered as a proliferative inhibitory role during cellular senescence, but the relevant mechanisms remain insufficient. This study aims to eluc...
ORGANISM(S): Homo Sapiens 
2025-01-16 | PXD059860 |
GenomicsRNA localization to nuclear speckles follows splicing logic
RNA localization to nuclear speckles follows splicing logic
PRJNA1418765 | ENA
GenomicsDistinct factors control histone variant H3.3 localization at specific genomic regions
The incorporation of histone H3 variants has been implicated in the epigenetic memory of cellular state. Using genome editing with zinc finger nucleases to tag endogenous H3.3, we report genome-wide profiles of H3 variants in mammalian embryonic stem (ES) cells and neuronal precursor cells. Genome-w...
ORGANISM(S): Mus musculus 
2010-03-04 | E-GEOD-16893 | biostudies-arrayexpress
TranscriptomicsNuclear retention of fission yeast dicer is a prerequisite for RNAi-mediated heterochromatin assembly
RNAseIII ribonucleases act at the heart of RNA silencing pathways by processing precursor RNAs into mature microRNAs and siRNAs. In the fission yeast Schizosaccharomyces pombe, siRNAs are generated by the RNAseIII enzyme Dcr1 and are required for heterochromatin formation. In this study, we have ana...
ORGANISM(S): Schizosaccharomyces pombe 
2010-02-16 | E-GEOD-18582 | biostudies-arrayexpress
ProteomicsComparative membrane proteomics reveals diverse cell regulators concentrated at the nuclear envelope
The nuclear envelope (NE) is a subdomain of the ER with a distinctive protein composition that underpins its role in nuclear compartmentalization. To expand an understanding of NE functions, we refined methods to reveal low abundance transmembrane (TM) proteins concentrated at the NE. De facto, th...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2023-01-25 | MSV000091154 | MassIVE
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