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MetabolomicsQuantitative metabolomic analysis of changes in the lens and aqueous humor under development of age-related nuclear cataract

INTRODUCTION: Metabolites are essential for the proper functioning of the eye lens, they either enter the lens from the aqueous humor (AH), or are synthesized in the lens epithelium. Antioxidants, osmolytes and UV filters are especially important for the lens protection, and thei...

2022-11-07 | MTBLS740 | MetaboLights
ProteomicsNucleocytoplasmic transport and membrane growth control nuclear size
How cells control the overall size of membrane-bound organelles is an important unanswered question of cell biology. Fission yeast cells maintain a nuclear size that is proportional to cellular size, resulting in a constant ratio between the nuclear and cellular volumes (N/C ratio). To shed light on...
ORGANISM(S): Schizosaccharomyces pombe 
2017-06-05 | PXD004530 | Pride
Nuclear cell ratio Nuclear size Silac 
ModelsBudding yeast size control by titration of nuclear sites
This model is decribed in the article: Dilution and titration of cell-cycle regulators may control cell size in budding yeast Frank S. Heldt, Reece Lunstone, John J. Tyson, Bela Novak PLoS Comput Biol, October 2018, 14(10), e1006548, doi: 10.1371/journal.pcbi.1006548 Abstract: The size of a cell se...
2024-09-02 | BIOMD0000000856 | BioModels
ModelsHeldt2018 - Budding yeast size control by titration of nuclear sites
This model is decribed in the article: Dilution and titration of cell-cycle regulators may control cell size in budding yeast Frank S. Heldt, Reece Lunstone, John J. Tyson, Bela Novak PLoS Comput Biol, October 2018, 14(10), e1006548, doi: 10.1371/journal.pcbi.1006548 Abstract: The size of a cell se...
2019-01-09 | MODEL1803220002 | BioModels
TranscriptomicsCytoplasmic Assembly and Selective Nuclear Import of Arabidopsis ARGONAUTE4/siRNA Complexes
Here we profiled small RNAs from whole cell, cytoplasmic and nuclear extracts from three-week-old Arabidopsis seedlings. We unexpectedly found that nuclear functional hc-siRNAs are predominantly present in the cytoplasm. Samples from Arabidopsis thaliana whole cell, cytoplasmic and nuclear extract...
ORGANISM(S): Arabidopsis thaliana 
2012-07-12 | E-GEOD-36500 | biostudies-arrayexpress
GenomicsNuclear cholesterol regulates nuclear size and DNA damage responses in the tumor hierarchy
Nuclear cholesterol regulates nuclear size and DNA damage responses in the tumor hierarchy
PRJNA1035086 | ENA
TranscriptomicsScaling of gene expression with liver cell size in vivo
A partially hepatectomized mouse liver with a liver-specific conditional Cdk1 knock-out genotype grows back to the normal size in the absence of cell divisions resulting in highly enlarged nuclear and cell size. This experiment analyses gene expression in four sets of mouse livers all with different...
ORGANISM(S): Mus musculus 
2014-03-06 | E-MTAB-1297 | biostudies-arrayexpress
ProteomicsPANNEXIN-1 CHANNEL REGULATES NUCLEAR CONTENT PACKAGING INTO APOPTOTIC BODIES AND THEIR SIZE
Apoptotic bodies (ApoBDs), which are large extracullular vesicles exclusively released by apoptotic cells, possess therapeutically exploitable properties including biomolecule loadability and transferability. However, current limited understanding of ApoBD biology has hindered its exploration for cl...
ORGANISM(S): Homo sapiens (Human) 
2021-04-08 | PXD023988 | Pride
Pannexin 1 Apoptotic bodies Extracellular vesicles Nuclear proteins Dna Cargo sorting 
GenomicsSUN1/2 Controls Macrophage Polarization via Modulating Nuclear Size and Stiffness
SUN1/2 Controls Macrophage Polarization via Modulating Nuclear Size and Stiffness
PRJNA1019379 | ENA
TranscriptomicsNuclear cholesterol regulates nuclear size and DNA damage responses in the tumor hierarchy
Normal stem cells undergo morphologic, epigenetic, and metabolic changes during cellular differentiation. Here, we report that glioblastoma stem cells (GSCs) display smaller nuclear size than differentiated progeny. Leveraging differential gene expression and proteomics to discover potential mediato...
ORGANISM(S): Homo sapiens 
2025-05-03 | GSE246908 | GEO
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