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MetabolomicsPorcine epidemic diarrhea virus manipulates IMPDH-dependent nucleotide biosynthesis to facilitate replication

Porcine epidemic diarrhea virus (PEDV) causes acute intestinal disease in pigs and remains a major threat to the global swine industry due to its high morbidity and mortality in neonatal piglets. To investigate host metabolic alterations upon PEDV infection, we performed untargeted metabolomic pr...

2025-10-17 | MTBLS13153 | MetaboLights
MetabolomicsExahustive degradation of nucleotide triphosphates
Not available
ORGANISM(S): None 
ST000470 | MetabolomicsWorkbench
MetabolomicsNucleotide depletion signals early-stage soil stable carbon collapse in anthropogenically disturbed alpine ecosystems
Anthropogenic disturbances are a primary cause of soil organic carbon (SOC) destabilization in alpine ecosystems. However, effective management is hindered by a """"response delay"""" of macro metrics used to characterize stable carbon pools (e.g., microbial necromass carbon and aggregate associated...
2026-05-23 | MTBLS14572 | MetaboLights
MetabolomicsAn overlooked prebiotic: beneficial effect of dietary nucleotide supplementation on gut microbiota and metabolites in senescence-accelerated mouse prone-8 mice
Nucleotides (NTs) are regulatory factors in many biological processes and play important roles in the growth, development, and metabolism of living organisms. We used senescence-accelerated mouse prone-8 (SAMP8) to investigate the effects of NTs on the gut microbiota and metabolites. And the promoti...
2022-03-21 | MTBLS4012 | MetaboLights
MetabolomicsMulti-omic Profiling of Multi-Biosamples Reveals the Role of Amino Acid and Nucleotide Metabolism in Endometrial Cancer
Endometrial cancer (EC) is one of the most common gynecological cancers. Finding biomarkers of EC can support its diagnosis in a non- or minimally-invasive way. In this work, we integrated metabolomics and proteomics for the analysis of multiple types of biosamples to gain a more comprehensive view ...
2022-03-28 | MTBLS3935 | MetaboLights
MetabolomicsIDH1 Reprograms Nucleotide Metabolism by Inducing Chromatin Remodeling and DHODH Transcription to Drive Chemoresistance in Nasopharyngeal Carcinoma

Metabolic reprogramming under therapeutic stress may represent a targetable vulnerability for cancer treatment. Elucidation of the metabolic alterations linked to chemotherapy in nasopharyngeal carcinoma (NPC) could uncover potential therapeutic strategies. Using proteomics and transcriptomic pro...

2026-01-14 | MTBLS11531 | MetaboLights
MetabolomicsEffect of the chemical environment on the degradation of nucleotide triphosphates
Not available
ORGANISM(S): None 
ST000473 | MetabolomicsWorkbench
MetabolomicsEffect of the culture medium on the degradation of nucleotide triphosphates
Not available
ORGANISM(S): None 
ST000472 | MetabolomicsWorkbench
MetabolomicsEffect of a complex matrix on the degradation of nucleotide triphosphates
Not available
ORGANISM(S): None 
ST000471 | MetabolomicsWorkbench
MetabolomicsNucleotide Analysis following Adenylate Kinase 4 knockdown
Not available
ORGANISM(S): Homo sapiens 
ST000687 | MetabolomicsWorkbench
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