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MetabolomicsPorcine epidemic diarrhea virus manipulates IMPDH-dependent nucleotide biosynthesis to facilitate replication

Porcine epidemic diarrhea virus (PEDV) causes acute intestinal disease in pigs and remains a major threat to the global swine industry due to its high morbidity and mortality in neonatal piglets. To investigate host metabolic alterations upon PEDV infection, we performed untargeted metabolomic pr...

2025-10-17 | MTBLS13153 | MetaboLights
MetabolomicsUntargeted metabolomics reveals bovine viral diarrhea virus infection reprogram host nucleotide and amino acid metabolism in MDBK Cells

Bovine viral diarrhea virus (BVDV) is a highly adapted intracellular parasite that depends entirely on the host cell's metabolic resources and energy for the synthesis of viral components. However, the mechanisms by which BVDV remodels host lipid metabolism remain unclear. In this study, we explo...

2025-10-12 | MTBLS13126 | MetaboLights
MetabolomicsCoordinate Regulation of Metabolite Glycosylation and Stress Hormone Biosynthesis by TT8 in Arabidopsis
Secondary metabolites play a key role in coordinating ecology and defense strategies of plants. Diversity of these metabolites arise by conjugation of core structures with diverse chemical moieties, such as sugars in glycosylation. Active pools of phytohormones, including those involved in plant str...
2016-10-03 | MTBLS129 | MetaboLights
ProteomicsNucleotide sugar biosynthesis occurs in the glycosomes of procyclic and bloodstream form Trypanosoma brucei
In Trypanosoma brucei, there are fourteen enzymatic biotransformations that collectively convert glucose into five essential nucleotide sugars: UDP-Glc, UDP-Gal, UDP-GlcNAc, GDP-Man and GDP-Fuc. These biotransformations are catalyzed by thirteen discrete enzymes, five of which possess putative perox...
ORGANISM(S): Trypanosoma brucei 
2021-01-28 | PXD023124 | Pride
Nucleotide sugar biosynthesis Glycosome localization T. brucei 
GenomicsDisruption of nucleotide biosynthesis reprograms mitochondrial metabolism to inhibit adipogenesis
Disruption of nucleotide biosynthesis reprograms mitochondrial metabolism to inhibit adipogenesis
PRJNA1104286 | ENA
GenomicsRate Limiting Enzymes in Nucleotide Metabolism Synchronize Nucleotide Biosynthesis and Chromatin Formation [ATAC-Seq]
Rate Limiting Enzymes in Nucleotide Metabolism Synchronize Nucleotide Biosynthesis and Chromatin Formation [ATAC-Seq]
PRJNA1327867 | ENA
GenomicsRate Limiting Enzymes in Nucleotide Metabolism Synchronize Nucleotide Biosynthesis and Chromatin Formation [RNA-Seq]
Rate Limiting Enzymes in Nucleotide Metabolism Synchronize Nucleotide Biosynthesis and Chromatin Formation [RNA-Seq]
PRJNA1327860 | ENA
TranscriptomicsDisruption of nucleotide biosynthesis reprograms mitochondrial metabolism to inhibit adipogenesis
A key organismal response to overnutrition involves the development of new adipocytes through the process of adipogenesis. Preadipocytes sense changes in the systemic nutrient status and metabolites can directly modulate adipogenesis. We previously identified a role of de novo nucleotide biosynthesi...
ORGANISM(S): Mus musculus 
2024-04-29 | GSE265830 | GEO
MetabolomicsTrcrtB regulates carotenoids biosynthesis, stress tolerance, conidiation and pathogenicity in the postharvest pink rot fungus, Trichothecium roseum

Trichothecium roseum is a highly destructive postharvest pathogenic fungus that causes pink mold rot in various fruits and leads to significant agricultural and economic losses. While Phytoene is known to be crucial for phytopathogens, its roles in postharvest fungi, remain largely obsc...

2026-07-22 | MTBLS15120 | MetaboLights
GenomicsMettl3 maintains genome stability of erythroid cells via Mthfd1-mediated nucleotide biosynthesis
Mettl3 maintains genome stability of erythroid cells via Mthfd1-mediated nucleotide biosynthesis
PRJNA1271960 | ENA
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