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Synovial and bone marrow mesenchymal stem cells after intradiscally injection show regenerative effects of nucleus pulposus. Microarray analyses of rats were performed to investigate the closeness of the gene profiles between the nucleus pulposus cells and the synovial or bone marrow mesenchymal ste...
ORGANISM(S): Rattus norvegicus 
This study identifies proteins interacting with SIRT1 in nucleus pulposus cells. We performed a pulldown assay using anti-SIRT1 antibodies. The analysis identified 540 unique SIRT1-binding partners.
ORGANISM(S): Rattus norvegicus (Rat) 
2026-04-27 | PXD073166 | Pride
MicroRNAs expression profiling of human nucleus pulposus cells derived from patients with disc degeneration in comparison with those derived from patients with scoliosis as control. Two-condition experiment: control nucleus pulposus cells vs. degenerative nucleus pulposus cells. Biological replicate...
ORGANISM(S): Homo sapiens 
Assessment of the putative differential gene expression profiles in high osmolality-treated bovine nucleus pulposus intervertebral disc cells for a short (5 h) and a long (24 h) time period. Identification of novel genes up- or down-regulated as an early or a late response to hyperosmotic stress. A ...
ORGANISM(S): Bos taurus 
To evaluate the effect of Hypoxia-inducible factor 1-alpha inhibitor (HIF-1) in nucleus pulposus (NP) cells, human NP cells were lentivirally transduced with either control or FIH-1 targeted shRNA. Gene expression changes between samples from control and FIH-1 silenced cells were evaluated using a m...
ORGANISM(S): Homo sapiens 
Nucleus pulposus (NP) resides in hypoxic microenvironment due to the avascular structure of intervertebral disc (IVD). Intracellular lactate drives lysine lactylation (Kla) as a newly epigenetic modification. However, the impact of Kla on NPCs remains unknown. Using liquid chromatography-tandem mass...
ORGANISM(S): Rattus norvegicus (Rat) 
2025-05-06 | PXD048244 | Pride
The aim of this transcription profiling study was to identify novel genes that could be used to distinguish bovine Nucleus pulposus (NP) cells from articular cartilage (AC) and annulus fibrosus (AF) cells and to further determine their expression in normal and degenerate human intervertebral disc (I...
ORGANISM(S): Bos taurus 
To investigate whether SUV39H2 binds to PPP1CA in nucleus pulposus cells
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD042152 | Pride
To identify PPP1CA interactome in human nucleus pulposus cell
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD042397 | Pride
A transcriptome analysis of serum-starved nucleus pulposus cells
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