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TranscriptomicsNUDT21 Negatively Regulates PSMB2 and CXXC5 by Alternative Polyadenylation and Contributes to Hepatocellular Carcinoma Suppression
HCC is the third leading cause of cancer-related deaths worldwide. However, the molecular mechanisms underlying the progression of HCC is still largely elusive. NUDT21 (CFIm25) is an important mediator of 3′ UTR APA and demonstrates a causal relationship between alternative polyadenylation and cance...
ORGANISM(S): Homo sapiens 
2018-01-25 | E-MTAB-6368 | biostudies-arrayexpress
ProteomicsNudt21 controls cell fate by connecting alternative polyadenylation to chromatin signaling
Cell fate transitions involve rapid changes of gene expression patterns and global chromatin remodeling, yet the underlying regulatory pathways remain incompletely understood. Here, we used transcription-factor induced reprogramming of somatic cells into pluripotent cells to screen for novel regulat...
ORGANISM(S): Mus musculus (Mouse) 
2018-01-08 | PXD008078 | Pride
Nudt21 tmt 
GenomicsNudt21 KO and Nudt21 Hypomorph esophageal basal cells
Nudt21 KO and Nudt21 Hypomorph esophageal basal cells
PRJNA1180070 | ENA
GenomicsNUDT21 CUT&Tag in neuroblastoma
NUDT21 CUT&Tag in neuroblastoma
PRJNA1373240 | ENA
GenomicsNUDT21 knockdown RNA-seq in neuroblastoma II
NUDT21 knockdown RNA-seq in neuroblastoma II
PRJNA1368904 | ENA
GenomicsNUDT21 knockdown PAS-seq in neuroblastoma I
NUDT21 knockdown PAS-seq in neuroblastoma I
PRJNA1368905 | ENA
GenomicsNUDT21 lactylation reprograms alternative polyadenylation to promote cuproptosis resistance
NUDT21 lactylation reprograms alternative polyadenylation to promote cuproptosis resistance
PRJNA1198896 | ENA
GenomicsNUDT21 Shapes Macrophage Transcriptomes through alternative polyadenylation in ARDS
NUDT21 Shapes Macrophage Transcriptomes through alternative polyadenylation in ARDS
PRJNA1242320 | ENA
GenomicsNUDT21 alters glioma migration through differential alternative polyadenylation of LAMC1
NUDT21 alters glioma migration through differential alternative polyadenylation of LAMC1
PRJNA962545 | ENA
TranscriptomicsNudt21 KO and Nudt21 Hypomorph esophageal basal cells
Stem cells continually self-renew and differentiate to sustain tissue homeostasis, yet the role of post-transcriptional mechanisms in guiding these processes remains incompletely understood. Here, we demonstrate that the regulation of 3’UTR length via alternative mRNA polyadenylation (APA) is essent...
ORGANISM(S): Mus musculus 
2025-11-21 | GSE280706 | GEO
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