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ProteomicsNudt21 controls cell fate by connecting alternative polyadenylation to chromatin signaling
Cell fate transitions involve rapid changes of gene expression patterns and global chromatin remodeling, yet the underlying regulatory pathways remain incompletely understood. Here, we used transcription-factor induced reprogramming of somatic cells into pluripotent cells to screen for novel regulat...
ORGANISM(S): Mus musculus (Mouse) 
2018-01-08 | PXD008078 | Pride
Nudt21 tmt 
ProteomicsA jack of all trades and a master of some: remodeling of signaling pathways downstream of CFIm 3’ end processing factor
The mammalian cleavage factor I (CFIm) has been implicated in alternative polyadenylation (APA) in a broad range of contexts, from cancers to learning deficits and parasite infections. To uncover the molecular pathways that translate CFIm expression levels into these observed phenotypes, we carried ...
ORGANISM(S): Homo sapiens (Human) 
2022-02-11 | PXD027034 | Pride
Tmt Phosphorylation Cfim3 
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