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ProteomicsCoordinate β-adrenergic inhibition of mitochondrial activity and angiogenesis arrest tumor growth
Mitochondrial metabolism has emerged as a promising target against the mechanisms of tumor growth. Herein, we have screened an FDA-approved library to identify drugs that inhibit mitochondrial respiration. The β1-blocker nebivolol specifically hinders oxidative phosphorylation in cancer cells by con...
ORGANISM(S): Homo sapiens (Human) 
2020-06-28 | PXD019750 | Pride
Human Rp-lc-ms/ms Cells 
ProteomicsMouse WAT mitochondrial bioenergetics LC-MSMS
Whether muscle mitochondrial dysfunction is the cause or consequence of metabolic disorders remains controversial. Herein, we demonstrate that inhibition of mitochondrial ATP synthase in muscle in vivo alters whole-body lipid homeostasis. Mice with restrained activity of the enzyme presented intrafi...
ORGANISM(S): Mus musculus (Mouse) 
2020-07-06 | PXD017678 | Pride
Mouse wat 
ProteomicsSkeletal Muscle from Mice fed with HFD LC-MSMS
Whether muscle mitochondrial dysfunction is the cause or consequence of metabolic disorders remains controversial. Herein, we demonstrate that inhibition of mitochondrial ATP synthase in muscle in vivo alters whole-body lipid homeostasis. Mice with restrained activity of the enzyme presented intrafi...
ORGANISM(S): Mus musculus (Mouse) 
2020-07-06 | PXD017683 | Pride
Mouse skeletal muscle hfd 
ProteomicsMouse Skeletal Muscle mitochondrial bioenergetics LC-MSMS
Whether muscle mitochondrial dysfunction is the cause or consequence of metabolic disorders remains controversial. Herein, we demonstrate that inhibition of mitochondrial ATP synthase in muscle in vivo alters whole-body lipid homeostasis. Mice with restrained activity of the enzyme presented intrafi...
ORGANISM(S): Mus musculus (Mouse) 
2020-07-06 | PXD017621 | Pride
Mouse skeletal muscle 
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