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ProteomicsCLPB disaggregase dysfunction impacts the functional integrity of the proteolytic SPY complex
CLPB is a mitochondrial intermembrane space AAA+ domain–containing disaggregase. CLPB mutations are associated with 3-methylglutaconic aciduria and neutropenia; however, the molecular mechanism underscoring disease and the contribution of CLPB substrates to disease pathology remains unknown. Interac...
ORGANISM(S): Homo sapiens (Human) 
2024-01-18 | PXD042313 | Pride
Disaggregase Protein transport Mitochondria Protein quality control Mitochondrial disease 
TranscriptomicsExpression data from mouse embryo during neural tube closure
This data series was used for two separate studies. The initial study was aimed to idenify expression changes brought about by the Cecr2Gt45Bic mutation during neural closure. The study included two different strains, BALB/cCrl in which Cecr2GT45Bic shows a neural tube defect phenotype and FVB/N in ...
ORGANISM(S): Mus musculus 
2012-02-27 | E-GEOD-30957 | biostudies-arrayexpress
TranscriptomicsExpression data between FOXP3 wild type and 2T>C(mut)
Investigation of the role of FOXP3 in CD4+ T effector cells. FOXP3 is transiently upregulated in T effector cells under activation. This temporary expression in Teff cells is insufficient to suppress expression of reported targets of FOXP3 repressor activity. The role of FOXP3 in T effector cells re...
ORGANISM(S): Homo sapiens 
2013-03-08 | E-GEOD-41087 | biostudies-arrayexpress
TranscriptomicsCharacterization of primary models of human trophoblast
To understand the human placenta development, we investigated the features of two trophoblast models, trophoblast organoids and trophoblast stem cells, with the aim of identifying which type of trophoblast in vivo they most closely resemble. To this end, we profiled the microRNAs from the two models...
ORGANISM(S): Homo sapiens 
2021-10-18 | E-MTAB-10438 | biostudies-arrayexpress
ModelsPokhilko2012_CircClock_RepressilatorFeedbackloop
This model is from the article: The clock gene circuit in Arabidopsis includes a repressilator with additional feedback loops Pokhilko A, Fernández AP, Edwards KD, Southern MM, Halliday KJ, Millar AJ. Mol Syst Biol.2012 Mar 6;8:574. 22395476, Abs...
2024-09-02 | BIOMD0000000412 | BioModels
ModelsLocke2005 - Circadian Clock
Locke2005 - Circadian Clock SBML model of the interlocked feedback loop network The model describes the circuit depicted in Fig. 4 and reproduces the simulations in Figure 5A and 5B. It provides initial conditions, parameter values and rules for the production...
2024-09-02 | BIOMD0000000055 | BioModels
TranscriptomicsCRISPR screen exploring resistance to AKTi (Capivasertib) in ER+ Breast Cancer in MCF7, T47D and CAMA-1 cell lines
A genome-wide CRISPR-Cas9 knockout screen was performed in the breast cancer cell lines T47D, MCF7, and CAMA-1 to identify genes modulating sensitivity and resistance to capivasertib, a selective AKT inhibitor. Cells were transduced with a CRISPR library, followed by treatment with capivasertib or v...
ORGANISM(S): Homo sapiens 
2026-05-25 | E-MTAB-16438 | biostudies-arrayexpress
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