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MetabolomicsGain-of-function genetic screens in human cells identify SLC transporters overcoming environmental nutrient restrictions

Solute carrier (SLC) transporters control fluxes of nutrients and metabolites across membranes and thereby represent a critical interface between the microenvironment and cellular and subcellular metabolism. Because of substantial functional overlap, the interplay and relative contributions of SL...

2022-09-20 | MTBLS4268 | MetaboLights
UnknownGain-of-function genetic screens in human cells identify SLC transporters overcoming environmental nutrient restrictions.
Not available
S-EPMC9481932 | biostudies-literature
UnknownCRISPR screens in physiologic medium reveal conditionally essential genes in human cells.
Not available
S-EPMC8172426 | biostudies-literature
UnknownCRISPR/Cas9 Screens Implicate RARA and SPNS1 in Doxorubicin Cardiotoxicity.
Not available
S-EPMC12922622 | biostudies-literature
UnknownDegradome-focused RNA interference screens to identify proteases important for breast cancer cell growth.
Not available
S-EPMC9598039 | biostudies-literature
UnknownCombined zebrafish-yeast chemical-genetic screens reveal gene-copper-nutrition interactions that modulate melanocyte pigmentation.
Not available
S-EPMC2938393 | biostudies-literature
UnknownCRISPR screens unveil nutrient-dependent lysosomal and mitochondrial nodes impacting intestinal tissue-resident memory CD8<sup>+</sup> T cell formation.
Not available
S-EPMC11590283 | biostudies-literature
UnknownForward genetic screens identified mutants with defects in trap morphogenesis in the nematode-trapping fungus Arthrobotrys oligospora.
Not available
S-EPMC8022932 | biostudies-literature
UnknownGenome-wide CRISPR screens reveal multitiered mechanisms through which mTORC1 senses mitochondrial dysfunction.
Not available
S-EPMC7848693 | biostudies-literature
TranscriptomicsMedium-dependent gene-expression profiling of the human K562 chronic myeloid leukemia cell line
Forward genetic screens across hundreds of diverse cancer cell lines have started to define the genetic dependencies of proliferating human cells and how these vary by genotype and lineage. Most screens, however, have been carried out in culture media that poorly resemble metabolite availability in ...
ORGANISM(S): Homo sapiens 
2021-03-01 | GSE164693 | GEO
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