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MetabolomicsLipidomic analysis of lipid droplets from murine hepatocytes reveals distinct signatures for nutritional stress
Liver steatosis can be induced by fasting or high-fat diet. We investigated by lipidomic analysis whether such metabolic states are reflected in the lipidome of hepatocyte lipid droplets (LDs) from mice fed normal chow diet (FED), fasted (FAS), or fed a high-fat diet (HFD). LC-MS/MS at levels of lip...
2014-08-19 | MTBLS26 | MetaboLights
MetabolomicsThe impact of genetic stress by ATGL deficiency on the lipidome of lipid droplets from murine hepatocytes
We showed earlier that nutritional stress like starvation or high fat diet resulted in phenotypic changes in the lipidomes of hepatocyte lipid droplets (LDs), representative for the pathophysiological status of the mouse model. Here we extend our former study by adding genetic stress due to knock-ou...
2014-08-19 | MTBLS81 | MetaboLights
MetabolomicsEffects of Different Nutritional Levels of Diets on Serum Metabolomics Profiles in Postpartum Tan Sheep
This study investigated the metabolomic characteristics of rumen fluid in postpartum New Zealand ewes after they were fed diets that met 100%, 115% or 130% of their nutritional requirements. Six ewes in each group collected individual blood samples at the time of their first estrus.
2026-07-25 | MTBLS15146 | MetaboLights
MetabolomicsVitamin D deficiency disrupts a host–microbiota bile acid axis in aged mice to drive Faecalibaculum rodentium expansion and intestinal epithelial barrier dysfunction
This study investigated how vitamin D deficiency alters the fecal metabolome and bile acid metabolism in mice and evaluated the contribution of Faecalibaculum rodentium bile salt hydrolase activity to intestinal epithelial barrier dysfunction. Two complementary mouse experiments were included. In th...
2026-08-07 | MTBLS15279 | MetaboLights
TranscriptomicsSelenium toxicity but not deficient or super-nutritional selenium status vastly alters the transcriptome in rodents
Protein and mRNA levels for several selenoproteins, such as glutathione peroxidase-1 (Gpx1), are down-regulated dramatically by selenium (Se) deficiency. Selenoprotein levels in rats increase sigmoidally with increasing dietary Se and reach defined plateaus at the Se requirement, making them sensiti...
ORGANISM(S): Rattus norvegicus 
2011-01-19 | E-GEOD-23895 | biostudies-arrayexpress
MetabolomicsA Phosphate starvation response gene (psr1-like) is present in Micromonas pusilla and other marine algae and coordinates the metabolic response to phosphate deficiency
Both marine phytoplankton and terrestrial plants have to deal with limited bioavailability of the key life nutrient, phosphate. In freshwater algae and plants, a phosphate starvation response gene (psr1) has been characterized, which encodes for a transcription factor that regulates the metabolic re...
2016-02-01 | MTBLS295 | MetaboLights
TranscriptomicsZinc deficiency impacts CO2 assimilation and disrupts copper homeostasis in Chlamydomonas reinhardtii
Zinc is an essential nutrient because of its role in catalysis and in stabilizing protein structure, but excess zinc can also be deleterious. Four nutritional zinc states have been identified in the alga Chlamydomonas reinhardtii: zinc toxic, zinc replete, zinc deficient and zinc limited. Growth is ...
ORGANISM(S): Chlamydomonas reinhardtii 
2013-05-03 | E-GEOD-41096 | biostudies-arrayexpress
TranscriptomicsGene expression profile of rice shoot in response to macronutrient deficiency
Macronutrients are pivotal elements for proper plant growth and development. We performed microarray analysis of rice shoot under nitrogen (N), phosphorus (P), and potassium (K) deficiency conditions to obtain a global view of gene regulations associated with plant response to essential nutrients. W...
ORGANISM(S): Oryza sativa Japonica Group 
2015-08-12 | E-GEOD-66935 | biostudies-arrayexpress
ProteomicsProteomic Analysis of Stationary Growth Stage and Nutritional Deficiency Adaptation Reveals Brucella Abortus Virulence Mechanisms
Brucellosis, an important bacterial zoonosis caused by Brucella species, has drawn increased attention around the world. As an intracellular pathogen, the ability of Brucella to deal with stress within the host cell is closely related to its virulence. The survival pressure on Brucella within a phag...
ORGANISM(S): Brucella abortus str. 2308 A 
2021-09-09 | PXD020869 | Pride
B. abortus  proteomics  logarithmic phase  stationary phase  nutritional stress 
TranscriptomicsTranscription profiling of mouse skin from K6/ODC animals response to folate deficient diets reveals folate deficiency enhances arsenic effects
We demonstrate that expression of key markers of keratinocyte differentiation is suppressed by exposure to sodium arsenite. Folate deficiency exacerbates this effect. In addition, cancer-related cell movement genes, and growth and proliferation genes are altered. Several redox-sensitive transcrip...
ORGANISM(S): Mus musculus 
2008-06-16 | E-GEOD-8733 | biostudies-arrayexpress
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