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GenomicsData access committee of the Prostate Cancer Research Center, University of Tampere, Finland.
Data Access Committee EGAC00001000423
EGAC00001000423 | EGA
TranscriptomicsTranscription profiling of mouse bone marrow-derived macrophages simulated with LPS, time series
The innate immune system is a two-edged sword; it is absolutely required for host defense against infection, but if left uncontrolled can trigger a plethora of inflammatory diseases. Here we used systems biology approaches to predict and validate a gene regulatory network involving a dynamic interp...
ORGANISM(S): Mus musculus 
2009-04-04 | E-GEOD-14769 | biostudies-arrayexpress
TranscriptomicsMicroarray analysis of differentially expressed genes in ovarian and fallopian tube epithelium from risk-reducing salpingo-oophorectomies
Mutations in BRCA1 and BRCA2 genes confer an increased lifetime risk for breast and ovarian cancer. Ovarian cancer risk can be decreased by risk-reducing salpingo-oophorectomy (RRSO). Studies on RRSO material have altered the paradigm of serous ovarian cancer pathogenesis. The purpose of this study ...
ORGANISM(S): Homo sapiens 
2015-02-28 | E-GEOD-66387 | biostudies-arrayexpress
Genomicsena-DATASET-BioMediTech-01-01-2016-11:07:07:068-452 - samples
We report the first combined analysis of whole genome sequence, detailed clinical history, and transcriptome sequence of multiple prostate cancer metastases in a single patient (A21). Whole genome and transcriptome sequence was obtained from 9 anatomically separate metastases, and targeted DNA sequ...
EGAD00001001869 | EGA
GenomicsIntegrated clinical, whole genome, and transcriptome analysis of multisampled lethal metastatic prostate cancer
We report the first combined analysis of whole genome sequence, detailed clinical history, and transcriptome sequence of multiple prostate cancer metastases in a single patient (A21). Whole genome and transcriptome sequence was obtained from 9 anatomically separate metastases, and targeted DNA sequ...
EGAS00001001659 | EGA
TranscriptomicsGene expression profiling of glioblastoma cell lines transfected with FGFR3-TACC3
Gene expression profiling of SNB19 and U251 glioblastoma cell lines transfected with the FGFR3-TACC3 fusion, FGFR3 wildtype and TACC3 wildtype constructs. SNB19 and U251 cells were transfected with different clones of the FGFR3-TACC3 fusion and with wildtype FGFR3 and TACC3 constructs. Total RNA was...
ORGANISM(S): Homo sapiens 
2012-12-01 | E-GEOD-42401 | biostudies-arrayexpress
TranscriptomicsIGFBP2 driven glioma progression is prevented by blocking a clinically significant network of integrin, ILK, and NK-kB
Insulin-like growth factor-binding protein 2 (IGFBP2) is increasingly recognized as a glioma oncogene, emerging as a target for therapeutic intervention. In this study, we used an integrative approach to characterizing the IGFBP2 network, combining transcriptional profiling of human glioma with vali...
ORGANISM(S): Homo sapiens 
2012-02-02 | E-GEOD-35467 | biostudies-arrayexpress
TranscriptomicsGenomic characterization of the MPNST
Malignant peripheral nerve sheath tumor (MPNST) is a rare sarcoma that lacks effective therapeutic strategies. By characterizing recurrent gene copy number aberrations, we gain insight into the most altered pathways with the purpose of scanning possible therapeutic targets. We conducted a microarray...
ORGANISM(S): Homo sapiens 
2011-11-26 | E-GEOD-33881 | biostudies-arrayexpress
TranscriptomicsProprotein Convertase Subtilisin/Kexin Type 7 (PCSK7) Is Essential for the Zebrafish Development and Bioavailability of Transforming Growth Factor β1a (TGFβ1a)
Proprotein convertase subtilisin/kexin (PCSK) enzymes convert proproteins into bioactive end products. Although other PCSK enzymes are known to be essential for biological processes ranging from cholesterol metabolism to host defense, the in vivo importance of the evolutionarily ancient PCSK7 has re...
ORGANISM(S): Danio rerio 
2014-01-02 | E-GEOD-42070 | biostudies-arrayexpress
TranscriptomicsThe tumorigenic fusion FGFR3-TACC3 escapes miR-99a regulation in glioblastoma
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2012-12-01 | E-GEOD-42402 | biostudies-arrayexpress
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