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UnknownPhase II Pilot Study of Vemurafenib in Patients With Metastatic BRAF-Mutated Colorectal Cancer.

Purpose

BRAF V600E mutation is seen in 5% to 8% of patients with metastatic colorectal cancer (CRC) and is associated with poor prognosis. Vemurafenib, an oral BRAF V600 inhibitor, has pronounced activity in patients with metastatic melanoma, but its activity in patients with BRAF V600E-posi...
S-EPMC4669589 | biostudies-literature
UnknownPhase 1 study of GSK3368715, a type I PRMT inhibitor, in patients with advanced solid tumors.

Background

GSK3368715, a first-in-class, reversible inhibitor of type I protein methyltransferases (PRMTs) demonstrated anticancer activity in preclinical studies. This Phase 1 study (NCT03666988) evaluated safety, pharmacokinetics, pharmacodynamics, and preliminary efficacy of GSK3368715 in...
S-EPMC10338470 | biostudies-literature
Genomicsena-DATASET-JHU-29-06-2015-20:17:30:536-212 - samples
Clinical Implications of Genomic Alterations in the Tumour and Circulation of Pancreatic Cancer Patients
EGAD00001001421 | EGA
GenomicsClinical Implications of Genomic Alterations in the Tumor and Circulation of Pancreatic Cancer Patients
Pancreatic adenocarcinoma has the worst mortality of any solid cancer. To evaluate the clinical implications of genomic alterations in this tumor type, we performed whole-exome analyses of 24 tumors, targeted genomic analyses of 77 tumors, and used non-invasive approaches to examine tumor-specific ...
EGAS00001001257 | EGA
GenomicsPancreatic Adenocarcinoma Data Access Committee
Data Access Committee EGAC00001000358
EGAC00001000358 | EGA
UnknownValidation of the OAKS prognostic model for acute kidney injury after gastrointestinal surgery.

Background

Postoperative acute kidney injury (AKI) is a common complication of major gastrointestinal surgery with an impact on short- and long-term survival. No validated system for risk stratification exists for this patient group. This study aimed to validate externally a prognostic model...
S-EPMC8855527 | biostudies-literature
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