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TranscriptomicsGene Expression Profiling Identifies Interferon Signalling Molecules and IGFBP3 in Human Degenerative Annulus Fibrosus
Low back pain is a major cause of disability especially for people between 20 and 50 years of age. As a costly healthcare problem, it imposes a serious socio-economic burden. Current surgical therapies have considerable drawbacks and fail to replace the normal disc in facilitating spinal movements a...
ORGANISM(S): Homo sapiens 
2015-10-23 | E-GEOD-70362 | biostudies-arrayexpress
TranscriptomicsOviduct-Embryo Interactions in Cattle: Two-Way Traffic or a One-Way Street?
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Bos taurus 
2015-11-04 | E-GEOD-74613 | biostudies-arrayexpress
TranscriptomicsOviduct-Embryo Interactions in Cattle: Two-Way Traffic or a One-Way Street? [Affymetrix]
The objective of this study was to examine the effect of the presence of a single or multiple embryo(s) on the transcriptome of the bovine oviduct. In Experiment 1, cyclic (non-bred, n = 6) and pregnant (artificially inseminated, n = 11) heifers were slaughtered on Day 3 after estrus, and the ampull...
ORGANISM(S): Bos taurus 
2015-11-04 | E-GEOD-74593 | biostudies-arrayexpress
TranscriptomicsSpatial Differences in Gene Expression in the Bovine Oviduct
The aim of this study was to compare the transcriptome of the different regions of the oviduct between pregnant and cyclic heifers. After synchronizing crossbred beef heifers, those in standing oestrus (=Day 0) were randomly assigned to cyclic (non bred, n=6), or pregnant (artificially inseminated, ...
ORGANISM(S): Bos taurus 
2016-03-01 | E-GEOD-75442 | biostudies-arrayexpress
TranscriptomicsSexually dimorphic gene expression in bovine conceptuses at the initiation of implantation is not reflected in the changes in the endometrial transcriptome.
In cattle, maternal recognition of pregnancy occurs on Day 16 via secretion of interferon tau (IFNT) by the conceptus. The endometrium can distinguish between embryos with different developmental competencies. In eutherian mammals, X-chromosome inactivation (XCI) is required to ensure an equal trans...
ORGANISM(S): Bos taurus 
2016-03-01 | E-GEOD-75754 | biostudies-arrayexpress
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