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TranscriptomicsTranscription profiling of human airway epithelium treated with azithromycin and SMM
Microarrays were used to evaluate the effects of azithromycin and an inflammatory stimulus (SMM) on human airway epithelium. Effects of azithromycin treatment were evaluated at 6, 24 and 48 hours. Effects of SMM were evaluated at 6 and 24 hours. In addition, pretreatment with azithromycin was used t...
ORGANISM(S): Homo sapiens 
2009-05-27 | E-GEOD-10592 | biostudies-arrayexpress
TranscriptomicsGene Expression in Transformed Lymphocytes Reveals Phenotype-Modifying Pathways in Cystic Fibrosis
Heritable genetic variants modify cystic fibrosis (CF) clinical phenotypes, e.g., lung disease, age-of-onset of persistent Pseudomonas aeruginosa (P. aeruginosa), and meconium ileus (MI).  Previous genome wide association studies (GWAS) have begun to inform the genetic architecture of CF phenotypes...
ORGANISM(S): Homo sapiens 
2016-05-19 | E-GEOD-60690 | biostudies-arrayexpress
TranscriptomicsEts homologous factor regulates pathways controlling response to injury in Calu-3 airway epithelial cells [RNA-seq]
Ets homologous factor (EHF) is an Ets family transcription factor expressed in many epithelial cell types including those lining the respiratory system. Disruption of the airway epithelium is central to many lung diseases, and a network of transcription factors coordinates its normal function. EHF c...
ORGANISM(S): Homo sapiens 
2014-12-23 | E-GEOD-63397 | biostudies-arrayexpress
TranscriptomicsmRNA expression data from whole trachea dissected from either wild-type mice or Scnn1b-Tg mice at post-natal days 0, 3, 10, and 42.
Scnn1b-Tg mice overexpress the beta subunit of the epithelial sodium channel (Scnn1b) in airway Club cells. The general phenotype of these mice is described in three published manuscripts (Mall et al. 2004, Nature Medicine, 10(5):487-93; Mall et al. 2008, Am J Respir Crit Care Med. 177(7):730-42; ...
ORGANISM(S): Mus musculus 
2014-09-11 | E-GEOD-47550 | biostudies-arrayexpress
TranscriptomicsmRNA expression data from lung (left lobe only) dissected from either wild-type mice or Scnn1b-transgenic mice at post-natal days 0, 3, 10, and 42.
Scnn1b-Tg mice overexpress the beta subunit of the epithelial sodium channel (Scnn1b) in airway Club cells. The general phenotype of these mice is described in three published manuscripts (Mall et al. 2004, Nature Medicine, 10(5):487-93; Mall et al. 2008, Am J Respir Crit Care Med. 177(7):730-42; ...
ORGANISM(S): Mus musculus 
2014-09-11 | E-GEOD-47546 | biostudies-arrayexpress
TranscriptomicsmRNA expression data from purified macrophages isolated from bronchoalveolar lavage fluid from either wild-type mice or Scnn1b-transgenic mice at post-natal days (PND) 0, 3, 10, and 42.
Scnn1b-Tg mice overexpress the beta subunit of the epithelial sodium channel (Scnn1b) in airway Club cells. The general phenotype of these mice is described in three published manuscripts (Mall et al. 2004, Nature Medicine, 10(5):487-93; Mall et al. 2008, Am J Respir Crit Care Med. 177(7):730-42; ...
ORGANISM(S): Mus musculus 
2014-09-11 | E-GEOD-47548 | biostudies-arrayexpress
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