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ProteomicsDevelopment of compounds for targeted degradation of mammalian cryptochrome proteins
The mammalian cryptochrome proteins (CRY1 and CRY2) are transcriptional repressors most notable for their role in circadian transcriptional feedback. Not all circadian rhythms depend on CRY proteins however, and the CRY proteins are promiscuous interactors that also regulate many other processes. In...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2025-01-22 | PXD058309 | Pride
Cryptochrome Circadian rhythm Degradation 
ProteomicsMacromolecular condensation buffers intracellular water potential
Optimum protein function and biochemical activity critically depends on water availability, because solvent thermodynamics drive protein folding and macromolecular interactions. Reciprocally, macromolecules restrict the movement of “structured” water molecules within their hydration layers, reducing...
ORGANISM(S): Mus musculus (Mouse) 
2023-09-22 | PXD044481 | Pride
Membraneless organelles Phase separation Water potential 
UnknownHeterozygous BTNL8 variants in individuals with multisystem inflammatory syndrome in children (MIS-C).
Not available
S-EPMC11586762 | biostudies-literature
UnknownGlobal anaesthesia practice using inguinal hernia surgery as a tracer condition: a secondary analysis of an international prospective cohort study.
Not available
S-EPMC12519944 | biostudies-literature
UnknownA prognostic model for use before elective surgery to estimate the risk of postoperative pulmonary complications (GSU-Pulmonary Score): a development and validation study in three international cohorts.
Not available
S-EPMC12056793 | biostudies-literature
UnknownEmpagliflozin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial.
Not available
S-EPMC10957483 | biostudies-literature
UnknownHigher dose corticosteroids in hospitalised COVID-19 patients requiring ventilatory support (RECOVERY): a randomised, controlled, open-label, platform trial.
Not available
S-EPMC11872607 | biostudies-literature
UnknownWorldwide trends in diabetes prevalence and treatment from 1990 to 2022: a pooled analysis of 1108 population-representative studies with 141 million participants.
Not available
S-EPMC7616842 | biostudies-literature
UnknownGeneral and abdominal adiposity and hypertension in eight world regions: a pooled analysis of 837 population-based studies with 7·5 million participants.
Not available
S-EPMC7616775 | biostudies-literature
UnknownHigher dose corticosteroids in patients admitted to hospital with COVID-19 who are hypoxic but not requiring ventilatory support (RECOVERY): a randomised, controlled, open-label, platform trial.
Not available
S-EPMC10156147 | biostudies-literature
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