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MetabolomicsRepurposing the orphan drug nitisinone to control the transmission of African trypanosomiasis
Tsetse transmit African trypanosomiasis, which is a disease fatal to both humans and animals. A vaccine to protect against this disease does not exist so transmission control relies on eliminating tsetse populations. Although neurotoxic insecticides are the gold standard for insect control, they neg...
2021-10-06 | MTBLS2166 | MetaboLights
ProteomicsTissue- and plasma-derived exosomal protein biomarkers define multiple human cancers
There is an unmet clinical need for improved tissue and liquid biopsy tools for cancer detection. We investigated the proteomic profile of exosomes in 426 human samples from tissue explants (TE), plasma and other bodily fluids. Among traditional exosome markers, CD9, HSPA8, ALIX, HSP90AB1 represent ...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2020-08-17 | PXD018301 | Pride
Exosomes  extracellular vesicles  proteomics  cancer  liquid biopsy  biomarkers  mass spectrometry  early cancer detection 
UnknownExtracellular Vesicle and Particle Biomarkers Define Multiple Human Cancers.
Not available
S-EPMC7522766 | biostudies-literature
UnknownFine-scale mapping of the 5q11.2 breast cancer locus reveals at least three independent risk variants regulating MAP3K1.
Not available
S-EPMC4289692 | biostudies-literature
UnknownFunctional variants at the 11q13 risk locus for breast cancer regulate cyclin D1 expression through long-range enhancers.
Not available
S-EPMC3617380 | biostudies-literature
UnknownVirologic Efficacy of Casirivimab and Imdevimab COVID-19 Antibody Combination in Outpatients With SARS-CoV-2 Infection: A Phase 2 Dose-Ranging Randomized Clinical Trial.
Not available
S-EPMC9379747 | biostudies-literature
UnknownThe Genetics of the Mood Disorder Spectrum: Genome-wide Association Analyses of More Than 185,000 Cases and 439,000 Controls.
Not available
S-EPMC8136147 | biostudies-literature
UnknownAssociation Between Tumor Necrosis Factor Inhibitors and the Risk of Hospitalization or Death Among Patients With Immune-Mediated Inflammatory Disease and COVID-19.
Not available
S-EPMC8524310 | biostudies-literature
UnknownSex-Dependent Shared and Nonshared Genetic Architecture Across Mood and Psychotic Disorders.
Not available
S-EPMC8458480 | biostudies-literature
UnknownBipolar multiplex families have an increased burden of common risk variants for psychiatric disorders.
Not available
S-EPMC7985020 | biostudies-literature
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