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TranscriptomicsPredicting the evolution of metastatic disease in breast cancer: results from 50 years of autopsies
This is a genomic analysis of breast cancer metastasis using array based CGH and is part of a large study investigating the patterns and evolution of metastases from breast cancer using autopsy material accumulated over the last 50 years from a single institution. The samples used in the genomic pro...
ORGANISM(S): Homo sapiens 
2013-11-11 | E-GEOD-46826 | biostudies-arrayexpress
TranscriptomicsApc restoration promotes cellular differentiation and reestablishes crypt homeostasis in colorectal cancer
The Adenomatous Polyposis Coli (APC) tumor suppressor is mutated in the vast majority of human colorectal cancers (CRC) and leads to deregulated Wnt signaling. To determine whether Apc disruption is required for tumor maintenance, we developed a mouse model of CRC whereby Apc can be conditionally su...
ORGANISM(S): Mus musculus 
2015-06-18 | E-GEOD-67186 | biostudies-arrayexpress
UnknownAdd-On Treatment With Zilebesiran for Inadequately Controlled Hypertension: The KARDIA-2 Randomized Clinical Trial.

Importance

In prior monotherapy studies of patients with hypertension, single subcutaneous doses of zilebesiran, an investigational RNA interference therapeutic, reduced serum angiotensinogen levels and systolic blood pressure (SBP) at 3 and 6 months.

Objective

To evaluate the efficac...
S-EPMC12120674 | biostudies-literature
UnknownGuidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).
Not available
S-EPMC4835977 | biostudies-literature
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