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ProteomicsAdipocytes alter the ALL translational programme to enhance their dormancy and stress resistance.
We investigated the possibility that adipocyte mediated stress protection is accompanied by activation of a selective mRNA translation analogous to stress induced translational arrest. Nalm-6 cells were subjected at +24 and +48h under 3T3-L1 adipocyte co-culture to Pulsed Stable Isotope Chromatograp...
ORGANISM(S): Homo sapiens (Human) 
2021-06-11 | PXD019369 | Pride
Stress resistance Acute lymphoblastic leukaemia (all) Translation Adipocyte niche 
UnknownA phase I/II study of KW-2478, an Hsp90 inhibitor, in combination with bortezomib in patients with relapsed/refractory multiple myeloma.
Not available
S-EPMC5672925 | biostudies-literature
UnknownAcute myeloid leukemia does not deplete normal hematopoietic stem cells but induces cytopenias by impeding their differentiation.
Not available
S-EPMC3746910 | biostudies-literature
UnknownClinical outcome of coronavirus disease 2019 in haemato-oncology patients.
Not available
S-EPMC7276898 | biostudies-literature
UnknownRandomized phase III study (ADMYRE) of plitidepsin in combination with dexamethasone vs. dexamethasone alone in patients with relapsed/refractory multiple myeloma.
Not available
S-EPMC6700046 | biostudies-literature
UnknownElotuzumab, lenalidomide, and dexamethasone in RRMM: final overall survival results from the phase 3 randomized ELOQUENT-2 study.
Not available
S-EPMC7474076 | biostudies-literature
UnknownAdipocytes disrupt the translational programme of acute lymphoblastic leukaemia to favour tumour survival and persistence.
Not available
S-EPMC8448863 | biostudies-literature
ProteomicsAdipocytes disrupt the translational programme of Acute Lymphoblastic Leukaemia to favour tumour survival and persistence
Nalm-6 cells co-cultured with 3T3-L1 adipocytes or pre-adipocytes were subjected to quantitative LC-MS/MS phosphoproteomic analysis at two timepoints (+24h and +72h) to determine dynamics of cell signalling. Two independent biological replicates were analysed per condition.
ORGANISM(S): Homo sapiens (Human) 
2021-06-09 | PXD019186 | Pride
Stress resistance Acute lymphoblastic leukaemia (all) Translation Adipocyte niche 
UnknownRNA-seq of newly diagnosed patients in the PADIMAC study leads to a bortezomib/lenalidomide decision signature.
Not available
S-EPMC6310235 | biostudies-literature
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