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TranscriptomicsHnRNPLL is a global regulator of alternative splicing in activated T cells
HnRNPLL was identified as a critical regulator of CD45 alternative splicing in a lentiviral shRNA screen. RNAi-mediated depletion of hnRNPLL eliminated the activation-induced induced transition from the CD45RA to the CD45RO isoform. HnRNPLL is induced during the process of T cell activation, raising...
ORGANISM(S): Homo sapiens 
2010-09-15 | E-GEOD-11834 | biostudies-arrayexpress
GenomicsCTCF promotes RNA pol II pausing and links DNA methylation to alternative splicing [ChIP-Seq]
The goal of this study was to investigate the role of intragenic CTCF in alternative pre-mRNA splicing through a combined CTCF-ChIP-seq and RNA-seq approach. CTCF depletion led to decreased inclusion of weak upstream exons. CTCF ChIP-seq was performed in BJAB and BL41 B cell lines and normalized rel...
ORGANISM(S): Homo sapiens 
2011-10-06 | E-GEOD-31485 | biostudies-arrayexpress
Transcriptomicsnaive/activated ANOVA group
In order to identify genes with differential gene expression or alternative splicing between the groups naive and activated we study 4 hybridizations on the Human Exon 1.0 ST array using mixed model analysis of variance. 1904 genes with significant gene expression differences between the groups and...
ORGANISM(S): Homo sapiens 
2010-09-21 | E-GEOD-11832 | biostudies-arrayexpress
TranscriptomicsLL-sh4/uninfected/shGFP ANOVA group
In order to identify genes with differential gene expression or alternative splicing between the groups LL-sh4, uninfected, and shGFP we study 6 hybridizations on the Human Exon 1.0 ST array using mixed model analysis of variance. 842 genes with significant gene expression differences between the g...
ORGANISM(S): Homo sapiens 
2010-09-15 | E-GEOD-11833 | biostudies-arrayexpress
TranscriptomicsCTCF promotes RNA pol II pausing and links DNA methylation to alternative splicing [RNA-Seq]
The goal of this study was to investigate the role of intragenic CTCF in alternative pre-mRNA splicing through a combined CTCF-ChIP-seq and RNA-seq approach. CTCF depletion led to decreased inclusion of weak upstream exons. CTCF ChIP-seq was performed in BJAB and BL41 B cell lines and normalized rel...
ORGANISM(S): Homo sapiens 
2011-10-06 | E-GEOD-31486 | biostudies-arrayexpress
TranscriptomicsCTCF promotes RNA pol II pausing and links DNA methylation to alternative splicing
This SuperSeries is composed of the following subset Series: GSE31485: CTCF promotes RNA pol II pausing and links DNA methylation to alternative splicing [ChIP-Seq] GSE31486: CTCF promotes RNA pol II pausing and links DNA methylation to alternative splicing [RNA-Seq] Refer to individual Series
ORGANISM(S): Homo sapiens 
2011-10-05 | E-GEOD-31278 | biostudies-arrayexpress
GenomicsEffects of dynamic cytosine methylation on alternative pre-mRNA splicing in T lymphocytes
Intragenic 5-methylcytosine and CTCF mediate opposing affects on pre-mRNA splicing: CTCF promotes inclusion of weak upstream exons through RNA polymerase II pausing, whereas 5-methylcytosine evicts CTCF, leading to exon exclusion. However, the mechanisms governing dynamic DNA methylation at CTCF bin...
ORGANISM(S): Homo sapiens 
2016-01-04 | E-GEOD-74850 | biostudies-arrayexpress
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