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ProteomicsProteomic and genomic characterization of a yeast model for Ogden Syndrome
Naa10 is a N-terminal acetyltransferase that, in a complex with its auxiliary subunit Naa15, co-translationally acetylates the -amino group of newly synthetized proteins as they emerge from the ribosome. Roughly 40-50% of the human proteome is acetylated by Naa10, rendering this an enzyme with one o...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2016-09-28 | PXD004923 | Pride
Ogden syndrome 
ProteomicsStructural, molecular and cellular impact of the Ogden syndrome mutant N-terminal acetyltransferase hNaa10-Ser37Pro
Abstract still has to be written. The obtained peptide mixtures were introduced into an LC-MS/MS system, the Ultimate 3000 (Dionex, Amsterdam, The Netherlands) in-line connected to an LTQ Orbitrap XL mass spectrometer (Thermo Fisher Scientific, Bremen, Germany). Samples were first loaded on a trapp...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2019-03-13 | MSV000083564 | MassIVE
TranscriptomicsProteomic and genomic characterization of a yeast model for Ogden syndrome [microarray]
Gene expression microarrays accompanying "Proteomic and genomic characterization of a yeast model for Ogden syndrome" by Doerfel et al 2016 in press at Yeast. Naa10 is a Na-terminal acetyltransferase that, in a complex with its auxiliary subunit Naa15, co-translationally acetylates the a-amino group...
ORGANISM(S): Saccharomyces cerevisiae 
2016-09-03 | GSE86358 | GEO
TranscriptomicsProteomic and genomic characterization of a yeast model for Ogden syndrome [RNA-seq and Ribo-seq]
Naa10 is a Nα-terminal acetyltransferase that, in a complex with its auxiliary subunit Naa15, co-translationally acetylates the α-amino group of newly synthetized proteins as they emerge from the ribosome. Roughly 40-50% of the human proteome is acetylated by Naa10, rendering this an enzyme with one...
ORGANISM(S): Saccharomyces cerevisiae 
2016-09-07 | GSE86466 | GEO
ProteomicsDifferential N-terminal COFRADIc analyses of Ogden fibroblasts
The X-linked lethal Ogden syndrome was the first reported human genetic disorder associated with a mutation in an N-terminal acetyltransferase gene. The affected males harbour a Ser37Pro mutation in the gene encoding hNaa10, the catalytic subunit of NatA, themajor human NAT. In order to understand t...
ORGANISM(S): Homo sapiens (Human) 
2016-04-12 | PXD001282 | Pride
Human Naa10 s37p mutation N-terminal acetylation Differential cofradic Fibroblasts Lc-ms/ms 
UnknownBiochemical and cellular analysis of Ogden syndrome reveals downstream Nt-acetylation defects.
Not available
S-EPMC4355026 | biostudies-literature
UnknownProteomic and genomic characterization of a yeast model for Ogden syndrome.
Not available
S-EPMC5248646 | biostudies-literature
UnknownLongitudinal Adaptive Behavioral Outcomes in Ogden Syndrome by Seizure Status and Therapeutic Intervention.
Not available
S-EPMC10996826 | biostudies-literature
UnknownCase report: Rare among ultrarare-Clinical odyssey of a new patient with Ogden syndrome.
Not available
S-EPMC9483008 | biostudies-literature
UnknownLongitudinal adaptive behavioral outcomes in Ogden syndrome by seizure status and therapeutic intervention.
Not available
S-EPMC11315639 | biostudies-literature
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