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UnknownA multi-layered network model identifies Akt1 as a common modulator of neurodegeneration.
Not available
S-EPMC10698508 | biostudies-literature
Genomicsmerged_dataset - samples
This dataset contains merged data from the 22 Hodgkin lymphoma and 5 reactive lymph node samples, including count data and cell cluster assignments.
EGAD00001006221 | EGA
Genomicsena-DATASET-BCCA-11-12-2019-18:47:10:446-1110 - samples
Single-cell gene expression was profiled for 22 Hodgkin lymphoma tumors and 5 reactive lymph nodes (2 replicates were performed for RLN-1). Library preparation was performed with the 10x Chromium platform (3' version 2 assay). Sequencing was performed on an Illumina NextSeq. The BAM files were gener...
EGAD00001005739 | EGA
GenomicsSingle-cell RNA sequencing of 22 Hodgkin lymphoma tumors and 5 reactive lymph nodes
Hodgkin lymphoma (HL) is characterized by an extensively dominant tumor microenvironment (TME) composed of different types of non-cancerous immune cells with rare malignant cells. Characterization of the cellular components and their spatial relationship is crucial to understanding crosstalk and the...
EGAS00001004085 | EGA
MetabolomicsVeterinary trypanocidal benzoxaboroles are peptidase-activated prodrugs (T. brucei assay)

Livestock diseases caused by Trypanosoma congolense, T. vivax and T. brucei, collectively known as nagana, are responsible for billions of dollars in lost food production annually. There is an urgent need for novel therapeutics. Encouragingly, promising antitrypanosomal benzoxaboroles are under v...

2020-09-23 | MTBLS1474 | MetaboLights
MetabolomicsVeterinary trypanocidal benzoxaboroles are peptidase-activated prodrugs (T. congolense assay)

Livestock diseases caused by Trypanosoma congolense, T. vivax and T. brucei, collectively known as nagana, are responsible for billions of dollars in lost food production annually. There is an urgent need for novel therapeutics. Encouragingly, promising antitrypanosomal benzoxaboroles are under v...

2020-10-22 | MTBLS1309 | MetaboLights
TranscriptomicsGenome-wide consequences of compromised NMD and their relavence for variable clinical phenotype of patients with UPF3B mutations [mRNA profiling]
Nonsense-mediated mRNA decay (NMD) surveillance pathways are best known to be involved in the degradation of mRNA with premature termination codons (PTCs). More recent studies demonstrate that the role of NMD pathways goes well beyond the degradation of PTC containing mRNA, into the regulation of ce...
ORGANISM(S): Homo sapiens 
2011-11-01 | E-GEOD-27125 | biostudies-arrayexpress
MetabolomicsProtein-metabolite interactomics of carbohydrate metabolism reveal regulation of lactate dehydrogenase

Metabolic networks are interconnected and influence diverse cellular processes. The protein-metabolite interactions that mediate these networks are frequently low affinity and challenging to systematically discover. We developed mass spectrometry integrated with equilibrium dialysis for the disco...

2023-08-07 | MTBLS7237 | MetaboLights
UnknownMulti-ancestry polygenic risk scores for the prediction of type 2 diabetes and complications in diverse ancestries.
Not available
S-EPMC12330429 | biostudies-literature
UnknownGenetic drivers of heterogeneity in type 2 diabetes pathophysiology.
Not available
S-EPMC10937372 | biostudies-literature
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