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TranscriptomicsExpression data from adult Myeloerythroid Progenitors (MP) ICN2 positive and adult Myeloerythroid Progenitors (MP) ICN2 negative
Notch signaling defines a conserved, fundamental pathway, responsible for determination in metazoan development and is widely recognized as an essential component of lineage specific differentiation and stem cell self-renewal in many tissues including the hematopoietic system. Until recently, the ma...
ORGANISM(S): Mus musculus 
2013-07-01 | E-GEOD-46724 | biostudies-arrayexpress
TranscriptomicsExpression data from adult Myeloerythroid Progenitors (MP) Hes1-GFP positive and adult Myeloerythroid Progenitors (MP) Hes1-GFP negative
Notch signaling defines a conserved, fundamental pathway, responsible for determination in metazoan development and is widely recognized as an essential component of lineage specific differentiation and stem cell self-renewal in many tissues including the hematopoietic system. Until recently, the ma...
ORGANISM(S): Mus musculus 
2013-07-01 | E-GEOD-46723 | biostudies-arrayexpress
TranscriptomicsExpression data from E13.5 Fetal Liver LSK Hes1-GFP positive and E13.5 Fetal Liver LSK Hes1-GFP negative
Notch signaling defines a conserved, fundamental pathway, responsible for determination in metazoan development and is widely recognized as an essential component of lineage specific differentiation and stem cell self-renewal in many tissues including the hematopoietic system. Until recently, the ma...
ORGANISM(S): Mus musculus 
2013-07-01 | E-GEOD-46725 | biostudies-arrayexpress
TranscriptomicsExpression data from adult LSK Hes1-GFP positive and adult LSK Hes1-GFP negative
Notch signaling defines a conserved, fundamental pathway, responsible for determination in metazoan development and is widely recognized as an essential component of lineage specific differentiation and stem cell self-renewal in many tissues including the hematopoietic system. Until recently, the ma...
ORGANISM(S): Mus musculus 
2013-07-01 | E-GEOD-46722 | biostudies-arrayexpress
TranscriptomicsIn Vivo Mapping of Notch Pathway Activity in Normal and Stress Hematopoiesis
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2013-07-01 | E-GEOD-46726 | biostudies-arrayexpress
TranscriptomicsExpression data from vehicle or PD-0332991 treated human T-ALL lines
Cyclin D3 is critical hematopoiesis and loss of cyclin D3 leads to resistance to transformation of bone marrow progenitors by Notch1-IC. We used a small molecule targeting cyclin D3:CDK4/6 activity to study whether its inhibition is an effective therapeutic strategy. We analyzed T-ALL lines in vitro...
ORGANISM(S): Homo sapiens 
2012-12-13 | E-GEOD-40635 | biostudies-arrayexpress
TranscriptomicsExpression data from LSK WT and LSK N1-C+
Notch signaling is one of the central regulators of differentiation in a variety of organisms and tissue types. Within the hematopoietic system, Notch is essential for the emergence of definitive HSC during fetal life and controls adult HSC differentiation to the T-cell lineage. Notch activation is ...
ORGANISM(S): Mus musculus 
2011-05-12 | E-GEOD-27799 | biostudies-arrayexpress
TranscriptomicsExpression data from LSK WT, GMP WT and GMP NcstnKO
Notch signaling is one of the central regulators of differentiation in a variety of organisms and tissue types. Within the hematopoietic system, Notch is essential for the emergence of definitive HSC during fetal life and controls adult HSC differentiation to the T-cell lineage. Notch activation is ...
ORGANISM(S): Mus musculus 
2011-05-12 | E-GEOD-27811 | biostudies-arrayexpress
TranscriptomicsExpression data from LSK WT and LSK NcstnKO
Notch signaling is one of the central regulators of differentiation in a variety of organisms and tissue types. Within the hematopoietic system, Notch is essential for the emergence of definitive HSC during fetal life and controls adult HSC differentiation to the T-cell lineage. Notch activation is ...
ORGANISM(S): Mus musculus 
2011-05-12 | E-GEOD-27794 | biostudies-arrayexpress
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