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TranscriptomicsA protective strategy against hyperinflammatory responses requiring the non-transcriptional actions of GPS2
The association between hyper-inflammatory states and numerous diseases is widely recognized, but our understanding of the molecular strategies that have evolved to prevent uncontrolled activation of inflammatory responses remains incomplete. Here, we report a critical, non-transcriptional role of G...
ORGANISM(S): Homo sapiens 
2012-03-23 | E-GEOD-35197 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of pituitary glands from wild type and LSD1 knock-out mice
Precise control of transcriptional programs underlying metazoan development is modulated by enzymatically active co-regulatory complexes, coupled with epigenetic strategies, but how specific members of histone modification enzyme families such as histone methyltransferases and demethylases are utili...
ORGANISM(S): Mus musculus 
2007-02-13 | E-TABM-223 | biostudies-arrayexpress
GenomicsPHF8 mediates histone demethylation events in cell cycle progression [ChIP-Seq]
While reversible histone modifications are linked to an ever-expanding range of biological functions, the demethylases for histone H4 lysine 20 and their potential regulatory roles remain unknown. Here, we report that the PHD and Jumonji C (JmjC) domain-containing protein, PHF8, while utilizing mul...
ORGANISM(S): Homo sapiens 
2010-09-01 | E-GEOD-22478 | biostudies-arrayexpress
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