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TranscriptomicsTranscription profiling of mouse left ventricle from male (-/-) (n=3) and (+/+) (n=4) at the age of 21M to do exercise and transcriptional analysis in male eNOS Knockout Mice
There is cardiac dysfunction in male eNOS (-/-) with age and 50% mortality at 21M. It was of interest to investigate the gene expression profile of aged eNOS (-/-) male in comparison to (+/+) in order to explore the genetic markers and molecular mechanisms leading to heart failure. RNA was extracted...
ORGANISM(S): Mus musculus 
2007-11-06 | E-GEOD-1988 | biostudies-arrayexpress
TranscriptomicsExpression data from pregnant rat hearts
Hyperhomocysteinemia (HHcy) causes cardiovascular dysfunction and is associated with many complications during pregnancy related to reduced NO bioactivity. The mechanisms of HHcy on the NO-dependent control of myocardial metabolism was compared with L-NAME, which directly inhibits NO bioavailability...
ORGANISM(S): Rattus norvegicus 
2015-06-12 | E-GEOD-30308 | biostudies-arrayexpress
TranscriptomicsOxidant-NO-dependent gene regulation in dogs with type I diabetes
The global changes in cardiac gene expression in dogs with alloxan-induced diabetes were studied using Affymetrix Canine Array. Cardiac RNA was extracted from the control and DM (n=4). The array data revealed that 797 genes were differentially expressed (P<0.01; fold change of at least ±2). 150 gene...
ORGANISM(S): Canis lupus familiaris 
2010-08-23 | E-GEOD-14887 | biostudies-arrayexpress
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