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UnknownSparse recurrent excitatory connectivity in the microcircuit of the adult mouse and human cortex.
Generating a comprehensive description of cortical networks requires a large-scale, systematic approach. To that end, we have begun a pipeline project using multipatch electrophysiology, supplemented with two-photon optogenetics, to characterize connectivity and synaptic signaling between classes of...
S-EPMC6158007 | biostudies-literature
UnknownConserved cell types with divergent features in human versus mouse cortex.
Elucidating the cellular architecture of the human cerebral cortex is central to understanding our cognitive abilities and susceptibility to disease. Here we used single-nucleus RNA-sequencing analysis to perform a comprehensive study of cell types in the middle temporal gyrus of human cortex. We id...
S-EPMC6919571 | biostudies-literature
UnknownAssociation of MTOR Mutations With Developmental Brain Disorders, Including Megalencephaly, Focal Cortical Dysplasia, and Pigmentary Mosaicism.

Importance

Focal cortical dysplasia (FCD), hemimegalencephaly, and megalencephaly constitute a spectrum of malformations of cortical development with shared neuropathologic features. These disorders are associated with significant childhood morbidity and mortality.

Objective

To identi...
S-EPMC4979321 | biostudies-literature
UnknownMorphoelectric and transcriptomic divergence of the layer 1 interneuron repertoire in human versus mouse neocortex.
Neocortical layer 1 (L1) is a site of convergence between pyramidal-neuron dendrites and feedback axons where local inhibitory signaling can profoundly shape cortical processing. Evolutionary expansion of human neocortex is marked by distinctive pyramidal neurons with extensive L1 branching, but whe...
S-EPMC11864503 | biostudies-literature
UnknownLocal connectivity and synaptic dynamics in mouse and human neocortex.
We present a unique, extensive, and open synaptic physiology analysis platform and dataset. Through its application, we reveal principles that relate cell type to synaptic properties and intralaminar circuit organization in the mouse and human cortex. The dynamics of excitatory synapses align with t...
S-EPMC9970277 | biostudies-literature
UnknownHuman neocortical expansion involves glutamatergic neuron diversification.
The neocortex is disproportionately expanded in human compared with mouse1,2, both in its total volume relative to subcortical structures and in the proportion occupied by supragranular layers composed of neurons that selectively make connections within the neocortex and with other telenc...
S-EPMC8494638 | biostudies-literature
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