Sort   by:  
 Page size 
TranscriptomicsGene expression profile of the neonatal female mouse brain after administration of testosterone propionate.
The aim of this study is to investigate the gene expression profiles during masculinization of neonatal female mice brain by exogenous androgen treatment. The results of our expression analysis will shed light on the identification of the key molecules of sexual differentiation of mammalian brain. E...
ORGANISM(S): Mus musculus 
2015-07-31 | E-GEOD-59375 | biostudies-arrayexpress
TranscriptomicsSirt1, p53 and p38MAPK are crucial regulators of detrimental phenotypes of ESCs with Max expression ablation
Ablation of expression of the Max gene encoding a Myc protein partner in ES cells provoked two major phenomena, i.e. loss of pluripotency and apoptotic cell death. We found that nicotinamide (Nam) significantly alleviates these Max expression ablation-coupled phenotypes in ES cells. To see the allev...
ORGANISM(S): Mus musculus 
2012-08-28 | E-GEOD-37917 | biostudies-arrayexpress
TranscriptomicsThe forced expression of Nanog or Esrrb allows preserve ESC status in the absence of nucleostemin expression
Nucleostemin (NS) gene is known to be expressed in stem cells in general including embryonic stem cells (ESCs). Previous knockdown and knockout studies have demonstrated that NS is important for the preservation of their self-renewality and high levels of pluripotent marker gene expression in mouse ...
ORGANISM(S): Mus musculus 
2015-01-30 | E-GEOD-56797 | biostudies-arrayexpress
TranscriptomicsEffect of ablation of Max gene expression on ES cells cultured under conventional or 2i/Nam condition.
c-Myc is one of key players that are crucially involved in maintaining the undifferentiated state and the self-renewal of ESCs. To understand the mechanism by which c-Myc helps preserve these prominent characteristics of ESCs, we generated null-ES cells for the Max gene, which encodes the best chara...
ORGANISM(S): Mus musculus 
2011-07-19 | E-GEOD-27881 | biostudies-arrayexpress
TranscriptomicsMax as a biological blockade that restricts meiotic process in ESCs
We explored Max ablation-mediated up-regulation of germ-related genes, especially meiosis-related genes in mouse embryonic stem cells which were cultured either under conventional mouse ES medium or 2i condition using inhibitors against MEK and GSK3b. Effect of culture conditions (conventional mouse...
ORGANISM(S): Mus musculus 
2016-03-31 | E-GEOD-65700 | biostudies-arrayexpress
TranscriptomicsIdentification of Ccr4-Not complex as a regulator of transition from partial to genuine iPS cells
Partial induced pluripotent cells (iPSCs) are cell lines strayed from normal route from somatic cells to iPSCs and are immortalized. Mouse partial iPSCs are able to convert to real iPSCs by the exposure to 2i condition using MAPK and GSK3? inhibitors. However, the molecular mechanisms of this conver...
ORGANISM(S): Mus musculus 
2014-01-07 | E-GEOD-44339 | biostudies-arrayexpress
TranscriptomicsPre-miR-375_A549 vs. Pre-miR-NC#2 (Ambion) _A549
We investigated the functional significance of ASH1-inducible miR-375 in terms of biologic phenotypes of ASH1-positive lung cancer cells. To this end, we conducted genome-wide expression profiling analysis of miR-375-transfected A549 cells. Microarray analysis using a Whole Human Genome 4 x 44K Micr...
ORGANISM(S): Homo sapiens 
2011-10-31 | E-GEOD-31566 | biostudies-arrayexpress
TranscriptomicsASH1_A549 vs. vector control_A549
We performed genome-wide expression profiling of miRNAs in order to search for those significantly affected by ASH1 transduction in a lung cancer cell line. Microarray analysis was?conducted to examine miRNA expression profiles using a Human miRNA Microarray, pre-commercial version 6.0 (Agilent) wit...
ORGANISM(S): Homo sapiens 
2011-10-31 | E-GEOD-31565 | biostudies-arrayexpress
TranscriptomicsBMM_C3H/ARC_LPS_timecourse
Bone marrow derived macrophages (BMM) total RNA from C3H/ARC mice extracted after stimulation by LPS at different time points. Each time point stimulated with 10ug/ml LPS from Salmonella minnesota for the time indicated. The RNA from each BMM stimulated time point was labeled with Cy3 and compared w...
ORGANISM(S): Mus musculus 
2010-06-05 | E-GEOD-324 | biostudies-arrayexpress
TranscriptomicsBMM_C3H/HeJ_LPS_timecourse
Bone marrow derived macrophages (BMM) total RNA from C3H/ARC mice extracted after stimulation by LPS at different time points. Each time point stimulated with 10ug/ml LPS from Salmonella minnesota for the time indicated. The RNA from each BMM stimulated time point was labeled with Cy3 and compared w...
ORGANISM(S): Mus musculus 
2010-06-05 | E-GEOD-326 | biostudies-arrayexpress
Sort   by:  
 Page size