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UnknownCyclin B–Cdk1 inhibits protein phosphatase PP2A-B55 via a Greatwall kinase–independent mechanism
Not available
S-JCBD-201307160 | bioimages
TranscriptomicsInterferon and ribavirin treatment in a rhesus macaque model of novel Middle East respiratory syndrome coronavirus (MERS-CoV) infection (hCoV-EMC)
Microarray analysis of lungs (right lower lobe) on day 3 post-infection with MERS-CoV with and without treatment beginning 8 h post-infection with intravenous type I interferon (IFN) and ribavirin (RBV). Dosages are as follows: IFN a2b 5 million IU/kg s.c. q8, RBV loading dose 50mg/kg i.v.; RBV mai...
ORGANISM(S): Macaca mulatta 
2013-09-06 | E-GEOD-47957 | biostudies-arrayexpress
TranscriptomicsCynomolgus macaque model of H7N9 influenza infection
The objective of this study is to characterize the response to newly emerged, highly pathogenic H7N9 influenza virus isolated from human patients in 2013 in China. This study examines the pathogenesis of H7N9 influenza in cynomolgus macaques. The study compares lung lesions to adjacent right lowe...
ORGANISM(S): Macaca fascicularis 
2014-07-22 | E-GEOD-48976 | biostudies-arrayexpress
TranscriptomicsRhesus macaque model of hCoV-EMC respiratory infection
Microarray analysis of peripheral blood mononuclear cells (PBMCs), lungs, and lung lesions collected over the course of hCoV-EMC infection of 6 rhesus macaques. 6 rhesus macaques were infected intratracheally with hCoV-EMC. PBMCs were collected at days 0, 1, 3, and 6, and lungs were collected from s...
ORGANISM(S): Macaca mulatta 
2013-08-29 | E-GEOD-44542 | biostudies-arrayexpress
TranscriptomicsHost genetic diversity enables experimental Ebola hemorrhagic fever pathogenesis
Zaire ebolavirus (ZEBOV) is among the deadliest known human pathogens, causing severe hemorrhagic fever with high case fatality rates ranging from 70-90%. The lack of effective vaccines or treatment available for ZEBOV renders this pathogen as a significant global biodefense threat, as evidenced by...
ORGANISM(S): Mus musculus 
2014-05-01 | E-GEOD-57214 | biostudies-arrayexpress
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