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MetabolomicsUntargeted LC-MS metabolomic studies of Asteraceae species to discover inhibitors of Leishmania major dihydroorotate dehydrogenase

INTRODUCTION: Interesting data about the family Asteraceae as a new source of Leishmania major dihydroorotate dehydrogenase (LmDHODH) inhibitors are presented. This key macromolecular target for parasites causing neglected diseases catalyzes the fourth reaction of the de novo pyr...

2019-10-14 | MTBLS722 | MetaboLights
UnknownA COVID-19 Outbreak in a Rheumatology Department Upon the Early Days of the Pandemic.
Not available
S-EPMC7546334 | biostudies-literature
UnknownExploring Mannosylpurines as Copper Chelators and Cholinesterase Inhibitors with Potential for Alzheimer's Disease.
Not available
S-EPMC9864808 | biostudies-literature
UnknownGenetic architecture of congenital hypogonadotropic hypogonadism: insights from analysis of a Portuguese cohort.
Not available
S-EPMC11415827 | biostudies-literature
UnknownIn Vitro and In Vivo Effect of Peptides Derived from 14-3-3 Paracoccidioides spp. Protein.
Not available
S-EPMC7828505 | biostudies-literature
UnknownNeuro-COVID frequency and short-term outcome in the Northern Portuguese population.
Not available
S-EPMC8250949 | biostudies-literature
UnknownPatient-physician discordance in assessment of adherence to inhaled controller medication: a cross-sectional analysis of two cohorts.
Not available
S-EPMC6858182 | biostudies-literature
ProteomicsFGF2 antiproliferative stimulus triggers proteomic and transcriptional changes associated with nucleolar disorganization in K-ras-driven mouse tumor cells (Nucleoli TMT)
Chromatin plays a crucial role in the intermediation between cell signaling and gene expression. The nucleolus is sensitive to stress and can orchestrate a chain of cellular events in response to stress signals. Despite being a growth factor, FGF2 has anti-proliferative and tumor-suppressive functio...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2022-10-12 | MSV000090518 | MassIVE
ProteomicsFGF2 antiproliferative stimulus triggers proteomic and transcriptional changes associated with nucleolar disorganization in K-ras-driven mouse tumor cells (CLASP MudPIT data)
Chromatin plays a crucial role in the intermediation between cell signaling and gene expression. The nucleolus is sensitive to stress and can orchestrate a chain of cellular events in response to stress signals. Despite being a growth factor, FGF2 has anti-proliferative and tumor-suppressive functio...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2022-10-12 | MSV000090516 | MassIVE
ProteomicsFGF2 antiproliferative stimulus triggers proteomic and transcriptional changes associated with nucleolar disorganization in K-ras-driven mouse tumor cells (Chromatin MudPIT data)
Chromatin plays a crucial role in the intermediation between cell signaling and gene expression. The nucleolus is sensitive to stress and can orchestrate a chain of cellular events in response to stress signals. Despite being a growth factor, FGF2 has anti-proliferative and tumor-suppressive functio...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2022-10-11 | MSV000090511 | MassIVE
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