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TranscriptomicsTranscription profile of colon biopsies from normal (NOR) donors, patients, underwent resection for CRC (M-CRC) and patients carriers of mutations predisposed to HNPCC (HNPC)
The challenge of preventing colorectal cancer (CRC) is the early identification of individuals whose apparently normal colorectal mucosa will develop cancer, because of inherited trait or environmental exposure. We sought to use genome-wide expression profiling of endoscopic biopsies to detect a sig...
ORGANISM(S): Homo sapiens 
2013-11-30 | E-GEOD-23011 | biostudies-arrayexpress
TranscriptomicsMucosal biopsies from groups Normal (NOR) and patients who underwent curative large bowel resection for colorectal cancer (M-CRC)
The challenge of preventing colorectal cancer (CRC) is the early identification of individuals whose apparently normal colorectal mucosa will develop cancer, because of inherited trait or environmental exposure. We sought to use genome-wide expression profiling of endoscopic biopsies to detect a sig...
ORGANISM(S): Homo sapiens 
2013-11-30 | E-GEOD-23194 | biostudies-arrayexpress
TranscriptomicsExpression profiles of human primary osteoblasts (HOB) and MET transformed osteoblast clones
We studied MET-transformed human primary osteoblasts (MET-HOBs), which we previously turned into osteosarcoma cells by LV driven over-expression of MET oncogene. We obtained distinct MET transformed HOB clones derived from independent events of transgene integration. To characterise the phenotype o...
ORGANISM(S): Homo sapiens 
2013-02-28 | E-GEOD-28256 | biostudies-arrayexpress
TranscriptomicsExpression profiles osteosarcoma cell lines and MET transformed osteoblast clones
We studied MET-transformed human primary osteoblasts (MET-HOBs), which we previously turned into osteosarcoma cells by LV driven over-expression of MET oncogene. We obtained distinct MET transformed HOB clones derived from independent events of transgene integration. To characterise the phenotype o...
ORGANISM(S): Homo sapiens 
2013-02-28 | E-GEOD-28252 | biostudies-arrayexpress
TranscriptomicsTranscriptional response of ovarian cancer cell lines to HGF and CDDP
HGF sensitizes ovarian cancer cells to chemotherapeutics, e.g. cisplatin (CDDP), through a signaling cascade activated by its MET oncogene encoded receptor and transduced by the p38MAPK. This cascade results in the regulation of a common set of transcripts in three ovarian cancer cell lines, with di...
ORGANISM(S): Homo sapiens 
2013-12-31 | E-GEOD-24589 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiles of MET transformed osteoblast clones (MET-HOB) and mesenchymal stem cells (MSC) where osteoblast differentiation was induced
The osteogenic differentiation process consists in a well-coordinated multi-step sequence of events, in which each stage is characterized by the expression of distinct protein markers, as well as by individual morphological features. In order to precisely identify the step at which cells are permiss...
ORGANISM(S): Homo sapiens 
2013-02-28 | E-GEOD-28205 | biostudies-arrayexpress
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