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MetabolomicsGut microbiota and fermentation-derived branched chain hydroxy acids mediate health benefits of yogurt consumption in obese mice
Meta-analyses suggest that yogurt consumption reduces type 2 diabetes incidence in humans, but the molecular basis of these observations remains unknown. Here we show that dietary yogurt intake preserves whole-body glucose homeostasis and prevents hepatic insulin resistance and liver steatosis in a ...
2022-02-03 | MTBLS442 | MetaboLights
TranscriptomicsRNA-seq expression profiling of humain MAIT cells in blood and liver as compared to mainstream TCD4+ and TCD8+ cells.
At variance with what is observed in mice, no distinct MAIT1 or MAIT17 subsets exist in human blood, as all MAIT cells express a variety of transcription factors such as Rorgt, Tbet, Eomes and Helios. However, they are also found in tissues in which they have specific effector functions. To determin...
ORGANISM(S): Homo sapiens 
2018-12-03 | E-MTAB-7143 | biostudies-arrayexpress
MetabolomicsProMetIS, deep phenotyping of mouse models by combined proteomics and metabolomics analysis

Genes are pleiotropic and getting a better knowledge of their function requires a comprehensive characterization of their mutants. Here, we generated multi-level data combining phenomic, proteomic and metabolomic acquisitions from plasma and liver tissues of two C57BL/6 N mouse models lacking the...

2021-09-01 | MTBLS1903 | MetaboLights
ModelsBexkens2024 - Schistosoma mansoni glycolysis
A kinetic model of S. mansoni glycolysis in which we can vary the allosteric regulation on lactate dehydrogenase (LDH). Because not enough kinetic data are available for all the schistosome enzymes to construct a complete schistosome glycolysis model de novo, we here adjusted the well-established gl...
2024-04-04 | MODEL2208290002 | BioModels
TranscriptomicsTranscriptomic analysis of human breast and prostate cancer cell lines on lysophosphatidic acid (LPA) stimulation
LPA is a natural bioactive lipid with growth factor-like functions due to activation of series of six G protein-coupled receptors (LPA1-6). In this study we determine the LPA induced early-gene expression profile in three unrelated human cancer cell lines (MDA-MB-231, MCF7, PC3) with an objective to...
ORGANISM(S): Homo sapiens 
2014-05-16 | E-GEOD-56265 | biostudies-arrayexpress
Genomics
Sorex araneus (European shrew) genome, mSorAra2
PRJNA922145 | ENA
GenomicsSorex araneus isolate:mSorAra2
Sorex araneus (European shrew) genome, mSorAra2, alternate haplotype
PRJNA916524 | ENA
GenomicsSorex araneus isolate:mSorAra2
Sorex araneus (European shrew) genome, mSorAra2, primary haplotype
PRJNA916523 | ENA
UnknownMembrane-associated effluxosomes coordinate multi-metal resistance in Mycobacterium tuberculosis
Not available
S-SCDT-10_1038-S44318-026-00715-1 | biostudies-other
TranscriptomicsDual IRE1 RNase functions dictate glioblastoma development
The transcriptome dataset has been used to validate on a GBM patient cohort (n=117) the IRE1-dependent gene expression signature identified in U87 cell line.
ORGANISM(S): Homo sapiens 
2018-01-09 | E-MTAB-6326 | biostudies-arrayexpress
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