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GenomicsFunctional link between Rad2 and Mediator
In this study, we generate genomic maps of Mediator, Rad2, Pol II, TBP and TFIIH, by ChIP coupled to next generation sequencing technology (ChIP-seq), in wild type strains from Saccharomyces cerevisiae. A related study involving ChIP-chip analysis of Rad2 occupany is also deposited at ArrayExpress ...
ORGANISM(S): Saccharomyces cerevisiae 
2013-12-01 | E-MTAB-1595 | biostudies-arrayexpress
GenomicsGenomic binding of Pol III transcription machinery and relationship with TFIIS distribution in mouse embryonic stem cells
RNA polymerase (RNA Pol) III synthesizes the tRNAs, the 5S ribosomal RNA and a small number of untranslated RNAs. In vitro, it also transcribes short interspersed nuclear elements (SINEs). We investigated the distribution of RNA Pol III and its associated transcription factors on the genome of mouse...
ORGANISM(S): Mus musculus 
2011-09-16 | E-MTAB-767 | biostudies-arrayexpress
ProteomicsTEAD inhibitor K-975 enhances KRASG12C inhibitor adagrasib-mediated cancer cell proliferation inhibition via dual cell cycle arrest
Here we investigate the effect of the dual inhibition, in KRASG12C mutated NSCLC cells, using the KRASG12Ci adagrasib (MRTX849) and the pan-TEAD inhibitor (TEADi) K-975. We show that K-975 enhances adagrasib-induced tumor cell growth inhibition in cancer cells. Mechanistically, we detect a downregul...
ORGANISM(S): Homo Sapiens (human) 
2023-05-12 | PXD039726 | JPOST Repository
ProteomicsInternalization of therapeutic antibodies into Dendritic cells as a risk factor for immunogenicity
The appended raw files, csv files and other documents were deposited into the public domain in support for the publication "Internalization of therapeutic antibodies into Dendritic cells as a risk factor for immunogenicity" by Michel Siegel, Anna-Lena Bolender, Axel Ducret, Johannes Fraidling, Katha...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-08-26 | MSV000095695 | MassIVE
ProteomicsDevelopment and qualification of a dendritic cell internalization assay contributing to the immunogenicity risk evaluation of biotherapeutics
The appended raw files, csv files and other documents were deposited into the public domain in support for the publication "Development and characterization of a dendritic cell internalization assay contributing to the immunogenicity risk evaluation of biotherapeutics" by Michel Siegel, Aman Padamse...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-08-12 | MSV000095578 | MassIVE
TranscriptomicsTranscription profiling of human ductal and lobular breast cancers with familial or Cowden disease history.
A Cartes d'Identite des Tumeurs (CIT) project from the french Ligue Nationale Contre le Cancer (http://cit.ligue-cancer.net) | 74 samples on Affymetrix HG-U133 Plus 2.0 GeneChips arrays for 74 patients. 5 samples on CGH CIT v7 | Breast carcinoma is the main malignant tumor occurring in patients wit...
ORGANISM(S): Homo sapiens 
2010-07-29 | E-TABM-854 | biostudies-arrayexpress
UnknownAssessing the antimicrobial activity of polyisoprene based surfaces.
Not available
S-EPMC4394427 | biostudies-literature
TranscriptomicsNef Gene expression during sex determination
Expression profiles of XX and XY somatic gonadal compartment during sex determination. This experiment was updated in March 2011 to correct the incorrect age value for sample Female E10.5_6 (was 11 days should be 10.5).
ORGANISM(S): Mus musculus 
2006-01-01 | E-MEXP-454 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human enterocytes cultured with different dietary lipids
The present study aimed to identify the specific impact of dietary lipids-containing micelles on gene expression in enterocytes.
ORGANISM(S): Homo sapiens 
2008-08-27 | E-MEXP-1446 | biostudies-arrayexpress
TranscriptomicsA new subtype of bone sarcoma defined by BCOR-CCNB3 gene fusion
The identification of subtype-specific translocations has revolutionized diagnostics of sarcoma and provided new insight into oncogenesis. We used RNA-Seq to investigate samples diagnosed as small round cell tumors of bone, possibly Ewing sarcoma, but lacking the canonical EWSR1-ETS translocation. A...
ORGANISM(S): Homo sapiens 
2012-03-03 | E-GEOD-34800 | biostudies-arrayexpress
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