Sort   by:  
 Page size 
GenomicsIdentification of Myc and Max genomic targets in mouse embryonic stem cells.
Myc is a master transcription factor that has been demonstrated to be required for embryonic stem cell (ESC) pluripotency, self-renewal, and inhibition of differentiation. Although recent works identified several Myc-targets in ESC the list of Myc binding sites is largely incomplete due to the low s...
ORGANISM(S): Mus musculus 
2014-03-05 | E-GEOD-48175 | biostudies-arrayexpress
GenomicsTranscriptional regulation of Tet1 during development
5-hydroxymethylcytosine (5hmC) is a recently discovered epigenetic modification that is lost in human cancers. Formation of 5hmC is catalysed by the Ten eleven translocation (TET) proteins that mediate the sequential oxidation of 5-methylcytosine (5mC) to 5hmC, leading to eventual DNA demethylation....
ORGANISM(S): Mus musculus 
2015-08-04 | E-GEOD-57250 | biostudies-arrayexpress
TranscriptomicsRetinoic acid induces Snai1 in stem cells of the preimplantation blastocyst to initiate differentiation
Although much is known about the pluripotency self-renewal circuitry, the molecular events that lead embryonic stem cells (ESCs) exit from pluripotency and begin differentiation are largely unknown. We found that the zinc finger transcription factor Snai1, involved in gastrulation and epithelial- me...
ORGANISM(S): Mus musculus 
2015-01-12 | E-GEOD-57854 | biostudies-arrayexpress
GenomicsDnmt3L-dependent regulation of DNA methylation promotes stem cells differentiation toward primitive germinal cells [ChIP-seq]
The de novo DNA methyltransferase 3-like (Dnmt3L) is a catalytically inactive DNA methylase that has been previously shown to cooperate with Dnmt3a and Dnmt3b to methylate DNA. Dnmt3L is highly expressed in mouse embryonic stem cells (ESC) but its function in these cells is unknown. We here report t...
ORGANISM(S): Mus musculus 
2013-09-27 | E-GEOD-49178 | biostudies-arrayexpress
GenomicsDnmt3L-dependent regulation of DNA methylation promotes stem cells differentiation toward primitive germinal cells [MeDIP-seq]
The de novo DNA methyltransferase 3-like (Dnmt3L) is a catalytically inactive DNA methylase that has been previously shown to cooperate with Dnmt3a and Dnmt3b to methylate DNA. Dnmt3L is highly expressed in mouse embryonic stem cells (ESC) but its function in these cells is unknown. We here report t...
ORGANISM(S): Mus musculus 
2013-09-27 | E-GEOD-44642 | biostudies-arrayexpress
GenomicsGenome-wide analysis identifies a functional association of Tet1 and Polycomb PRC2 in mouse embryonic stem cells but not in differentiated tissues
Recent studies have analyzed the distribution and role of 5-hydroxymethylcytosin (5hmC) in Embryonic Stem Cells (ESC). However, DNA hydroxymethylation occurs also in differentiated cells and it is significantly deregulated in cancer. Here we mapped 5hmC genome-wide profile in pluripotent ES cells in...
ORGANISM(S): Mus musculus 
2013-08-10 | E-GEOD-44566 | biostudies-arrayexpress
GenomicsSingle base resolution analysis of 5-formyl and 5-carboxyl cytosine reveals the actual promoter DNA methylation dynamics in embryonic stem cells [ChIP-Seq]
DNA methylation is catalysed by DNA methyltransferases (DNMTs) and is necessary for a correct embryonic development. On the other hand, the DNA demethylation is mediated by the Ten Eleven Translocation (Tet) proteins through oxidation of 5-methyl cytosine (5mC) to 5-hydroxyl (5hmC), 5-formyl (5fC) a...
ORGANISM(S): Mus musculus 
2015-02-10 | E-GEOD-55657 | biostudies-arrayexpress
UnknownInvestigating the Interactions of Peptide Nucleic Acids with Multicomponent Peptide Hydrogels for the Advancement of Healthcare Technologies.
Not available
S-EPMC12111274 | biostudies-literature
GenomicsSingle base resolution analysis of 5-formyl and 5-carboxyl cytosine reveals the actual promoter DNA methylation dynamics in embryonic stem cells [MAB-Seq]
DNA methylation is catalysed by DNA methyltransferases (DNMTs) and is necessary for a correct embryonic development. On the other hand, the DNA demethylation is mediated by the Ten Eleven Translocation (Tet) proteins through oxidation of 5-methyl cytosine (5mC) to 5-hydroxyl (5hmC), 5-formyl (5fC) a...
ORGANISM(S): Mus musculus 
2015-02-10 | E-GEOD-55658 | biostudies-arrayexpress
TranscriptomicsRole of miRNAs in acute kidney injury recovery induced by mesenchymal stromal cells and derived extracellular vesicles.
Phenotypic changes induced by extracellular vesicles (EVs) have been implicated in the recovery of acute kidney injury (AKI) induced by mesenchymal stromal cells (MSCs). miRNAs are potential candidates for cell reprogramming towards a pro-regenerative phenotype. The aim of the present study was to e...
ORGANISM(S): Mus musculus 
2015-05-07 | E-GEOD-59958 | biostudies-arrayexpress
Sort   by:  
 Page size