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TranscriptomicsBacterial Argonaute samples the transcriptome to identify foreign DNA
Eukaryotic Argonautes bind small RNAs and use them as guides to find complementary RNA targets and induce gene silencing. Though homologs of eukaryotic Argonautes are present in many bacteria and archaea their small RNA partners and functions are unknown. We found that the Argonaute of Rhodobacter s...
ORGANISM(S): Rhodobacter sphaeroides ATCC 17023 
2013-09-12 | E-GEOD-49865 | biostudies-arrayexpress
TranscriptomicsDe novo piRNA cluster formation in the Drosophila germline triggered by transgenes containing a transcribed transposon fragment
PIWI interacting RNAs (piRNAs) provide defense against transposable element (TE) expansion in the germline of metazoans. piRNAs are processed from the transcripts encoded by specialized heterochromatic clusters enriched in damaged copies of transposons. How these regions are recognized as a source o...
ORGANISM(S): Drosophila melanogaster 
2013-04-25 | E-GEOD-41780 | biostudies-arrayexpress
TranscriptomicsEuchromatic transposon insertions trigger production of novel pi- and endo-siRNAs at the target sites in the Drosophila germline
The control of transposable element (TE) activity in germ cells provides genome integrity over generations. A distinct small RNA-mediated pathway utilizing Piwi-interacting RNAs (piRNAs) suppresses TE expression in gonads of metazoans. In the fly, primary piRNAs derive from so-called piRNA clusters,...
ORGANISM(S): Drosophila melanogaster 
2014-02-07 | E-GEOD-46105 | biostudies-arrayexpress
TranscriptomicsProduction of artificial piRNAs in flies and mice
In animals, a discrete class of small RNAs, the piwi-interacting RNAs (piRNAs), guard germ cell genomes against the activity of mobile genetic elements. piRNAs are generated, via an unknown mechanism, from apparently single-stranded precursors that arise from discrete genomic loci, termed piRNA clus...
ORGANISM(S): Mus musculus 
2012-01-01 | E-GEOD-32435 | biostudies-arrayexpress
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