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ProteomicsApplying Proteomics and Computational Approaches to Identify Novel Targets in Blast Associated Post-Traumatic Epilepsy
Traumatic brain injury (TBI) remains a leading cause of post traumatic epilepsy (PTE). Blast TBI (bTBI) found in Veterans presents cognitive and behavioral disturbance such as PTE, however, the underlying mechanisms that drive the long-term sequelae are not well understood. Using an unbiased proteom...
ORGANISM(S): Mus musculus (Mouse) 
2024-06-22 | PXD048228 | Pride
Concussive brain injury Blast neurotrauma Traumatic brain injury Post traumatic epilepsy 
ProteomicsQuantitative Proteomic Analysis of an Alexander Disease Murine Model with Severe Reactive Gliosis
We performed label-free micro-data-independent acquisition (µDIA) to assay brain proteins from a severe model of Alexander disease (AxD, lethal at postnatal day ~35). Of the 5,005 proteins quantified, we observed upregulation of adipocytokine signaling, PPAR, insulin resistance, and glutathione pat...
ORGANISM(S): Mus musculus (Mouse) 
2021-11-30 | PXD021884 | Pride
Reactive gliosis Alexander disease Parallel reaction monitoring Data-independent acquisition Brain proteome 
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