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TranscriptomicsIntegrated genomic and prospective clinical studies show the importance of modular pleiotropy for disease susceptibility, diagnosis and treatment (dataset 2)
Medical research focuses on disease-specific genes. By contrast, here we systematically examined the roles of shared genes for disease susceptibility and as therapeutic and diagnostic targets. Meta-analysis of all published disease-related genome-wide association studies (GWAS) showed that T helper ...
ORGANISM(S): Homo sapiens 
2014-03-07 | E-GEOD-44964 | biostudies-arrayexpress
TranscriptomicsIntegrated genomic and prospective clinical studies show the importance of modular pleiotropy for disease susceptibility, diagnosis and treatment (dataset 1)
Medical research focuses on disease-specific genes. By contrast, here we systematically examined the roles of shared genes for disease susceptibility and as therapeutic and diagnostic targets. Meta-analysis of all published disease-related genome-wide association studies (GWAS) showed that T helper ...
ORGANISM(S): Homo sapiens 
2014-03-07 | E-GEOD-44956 | biostudies-arrayexpress
TranscriptomicsTasquinimod, a Quinoline-3-Carboxamide Anti-Angiogenic Agent, treated Prostate Cancer Cell Line in-vivo and in-vitro
The quinoline-3-carboxamide ABR-215050 (Tasquinimod (INN)), exhibits anti-tumor activity via inhibition of tumor angiogenesis in human and rodent tumors. To further explore the mode of action of ABR-215050, in vivo experiments with gene microarray analysis were performed using samples of LNCaP prost...
ORGANISM(S): Homo sapiens 
2011-03-01 | E-GEOD-17031 | biostudies-arrayexpress
GenomicsA validated gene regulatory network and GWAS identifies early regulators of T-cell associated diseases (ChIP-Seq)
For the purpose of the Gene Regulatory Network validation we have performed chromatin-immunoprecipitation sequencing (ChIP-Seq) experiment for three transcription factors; namely GATA3, MAF and MYB. ChIP-Seq of GATA3, MAF and MYB in human naïve CD4+ T-cells differentiated toward Th1 and Th2 until d...
ORGANISM(S): Homo sapiens 
2015-11-12 | E-GEOD-72266 | biostudies-arrayexpress
TranscriptomicsHuman cerebrospinal fluid autoantibody lipid microarray profiling (Fig. 1A)
Lipids comprise 70% of the myelin sheath, and autoantibodies against lipids may contribute to the demyelination that characterizes multiple sclerosis (MS). We used lipid antigen microarrays and lipid mass spectrometry to identify bona fide lipid targets of the autoimmune response in MS brain and an ...
ORGANISM(S): Homo sapiens 
2012-05-08 | E-GEOD-37664 | biostudies-arrayexpress
GenomicsNBS
WTCCC2 project samples from National Blood Donors (NBS) Cohort
EGAD00000000023 | EGA
GenomicsNBS
WTCCC2 project samples from National Blood Donors (NBS) Cohort
EGAD00000000024 | EGA
Genomics58C
WTCCC2 project samples from 1958 British Birth Cohort
EGAD00000000021 | EGA
Genomics58C
WTCCC2 project samples from 1958 British Birth Cohort
EGAD00000000022 | EGA
GenomicsMS
WTCCC2 project Multiple Sclerosis (MS) samples
EGAD00000000120 | EGA
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